Atrioventricular plane amplitudes and time intervals during titration with metoprolol CR/XL
| Baseline | 2 weeks | 4 weeks | 6 weeks | 24 weeks | RM ANOVA | |
|---|---|---|---|---|---|---|
| Values are mean (SD). 95% confidence intervals are of differences versus baseline. | ||||||
| AVP-FS, Atrioventricular plane fractional shortening; NS, not significant. | ||||||
| Metoprolol dose (mg) | 12.5 | 25 | 50 | 200 | ||
| Heart rate (beats/min) | 74 (11) | 67 (11) | 67 (13) | 62 (10) | 61 (11) | <0.001 |
| 95% CI | −10 to −2.9 | −13 to 0.3 | −16 to −6.7 | −17 to −7.7 | ||
| AVP-FS (%) | 7.8 (2.0) | 8.2 (2.4) | 8.2 (2.0) | 8.9 (2.8) | 9.5 (3.1) | <0.001 |
| 95% CI | −0.2 to 1.0 | −0.3 to 1.1 | 0.4 to 1.8 | 0.7 to 2.8 | ||
| Rapid filling amplitude (mm) | 3.1 (1.0) | 3.5 (1.4) | 3.5 (1.5) | 4.0 (1.8) | 3.8 (1.8) | 0.001 |
| 95% CI | −0.1 to 0.7 | −0.4 to 1.1 | 0.2 to 1.5 | −0.3 to 1.6 | ||
| Rapid filling maximal velocity (cm/s) | 39.9 (11) | 38.6 (11) | 40.3 (11) | 44.0 (11) | 41.8 (11) | NS |
| 95% CI | −4.9 to 2.3 | −3.2 to 3.9 | 0.6 to 7.5 | −3.5 to 7.3 | ||
| Atrial contraction amplitude (mm) | 4.7 (0.9) | 4.6 (1.1) | 4.9 (1.2) | 4.7 (0.9) | 4.7 (1.0) | NS |
| 95% CI | −0.6 to 0.4 | −0.5 to 0.9 | −0.8 to 0.2 | −0.6 to 0.8 | ||
| Atrial filling fraction (%) | 71 (26) | 64 (12) | 66 (15) | 60 (18) | 59 (13) | 0.001 |
| 95% CI | −17 to 3.0 | −19 to 9.3 | −20 to −5.9 | −24 to −0.5 | ||
| Q1-Q2 interval (ms) | 836 (130) | 920 (155) | 922 (160) | 989 (140) | 1010 (148) | <0.001 |
| 95% CI | 42 to 125 | 13 to 159 | 98 to 207 | 105 to 243 | ||
| Ejection time (ms) | 237 (35) | 249 (32) | 249 (27) | 263 (29) | 268 (32) | <0.001 |
| 95% CI | −2.1 to 26 | −3.1 to 28 | 17 to 36 | 14 to 48 | ||
| Rapid filling time (ms) | 87 (28) | 105 (33) | 103 (34) | 124 (33) | 128 (39) | <0.001 |
| 95% CI | 5.2 to 31 | −2.4 to 35 | 25 to 50 | 22 to 61 | ||
| Diastasis (ms) | 161 (76) | 212 (99) | 198 (90) | 263 (91) | 269 (107) | <0.001 |
| 95% CI | 9.1 to 84 | −0.9 to 76 | 71 to 124 | 60 to 155 | ||
| Atrial contraction time(ms) | 107 (19) | 117 (25) | 114 (22) | 120 (16) | 125 (18) | <0.001 |
| 95% CI | 3.3 to 16 | −2.5 to 15 | 3.3 to 23 | 8.9 to 27 | ||