Table 1

Lipid profile, haemodynamics, absolute forearm blood flow, and haematocrit at baseline and during placebo and pravastatin treatment

Patients
ControlsBaselinePlaceboPravastatin
Data are mean (SEM). Unpaired t test ***p<0.001 (controls versus patients at baseline); *p=0.04, **p=0.003 (patients: pravastatin versus controls); Paired t test *p=0.02, **p<0.003 (patients: placebo versus pravastatin); Analysis of variance *p=0.04, **p<0.002 (three way analysis of variance for patient groups).
HDL, high density lipoprotein; LDL, low density lipoprotein.
Age (years)43 (3)46 (3)
Sex (male:female)5:35:3
Body mass index (kg/m2)24 (1)25 (1)
Smokers33
Total cholesterol (mmol/l)5.0 (0.2)***8.1 (0.3)8.2 (0.3)6.4 (0.4)**
LDL cholesterol (mmol/l)3.2 (0.2)***5.8 (0.5)6.1 (0.5)4.3 (0.4)*
HDL cholesterol (mmol/l)1.1 (0.1)1.1 (0.1)1.1 (0.2)1.2 (0.2)
Triglycerides (mmol/l)1.5 (0.4)2.7 (0.4)2.3 (0.4)1.9 (0.3)
Mean arterial pressure (mm Hg)88 (5)87 (2)87 (4)87 (2)
Heart rate (beats/min)64 (2)62 (3)63 (5)62 (4)
Basal blood flow (mlL/100 ml/min)
    Non-infused arm3.0 (0.5)2.4 (0.3)2.9 (0.3)2.4 (0.3)
    Infused arm3.7 (0.7)3.6 (0.3)3.2 (0.3)2.5 (0.3)
Haematocrit0.39 (0.01)0.43 (0.01)0.42 (0.01)0.41 (0.01)