Table 3

Plasma plasminogen activator inhibitor type 1 (PAI-1) antigen and activity in patients at baseline and during placebo and pravastatin treatment and in matched controls

Patients
Substance P dose (pmol/min)ControlsBaselinePlaceboPravastatin
Data are mean (SEM).
PAI-1 antigen (ng/ml)
    Infused arm023 (9)40 (10)47 (12)48 (15)
224 (8)43 (10)47 (11)44 (13)
424 (8)41 (9)46 (11)51 (16)
829 (10)39 (9)46 (12)46 (14)
    Non-infused arm022 (8)44 (11)50 (13)50 (16)
223 (8)40 (9)51 (12)51 (18)
426 (9)39 (9)51 (14)46 (14)
828 (8)38 (9)48 (11)46 (14)
PAI-1 activity (AU/ml)
    Infused arm09 (3)13 (2)15 (3)13 (3)
210 (4)10 (2)16 (3)13 (2)
49 (4)9 (3)13 (3)14 (2)
811 (5)11 (3)13 (3)13 (2)
    Non-infused arm012 (3)14 (3)14 (3)15 (3)
28 (4)13 (2)16 (3)13 (2)
411 (5)10 (3)14 (2)13 (3)
89 (4)12 (3)13 (3)12 (3)