Repeatability of t-PA and blood flow responses to substance P administration in the infused forearm: baseline versus placebo
| Substance P dose (pmol/min) | Baseline mean | Placebo mean | Mean of differences | Coefficient of repeatability | |
|---|---|---|---|---|---|
| Data are mean (SEM). | |||||
| t-PA antigen (ng/ml) | 0 | 4.6 (0.8) | 4.7 (0.6) | 0.5 | 0.4 |
| 2 | 5.4 (0.8) | 5.4 (0.6) | 0.1 | 1.4 | |
| 4 | 5.7 (0.9) | 6.0 (0.9) | 0.6 | 1.4 | |
| 8 | 7.4 (1.1) | 7.5 (1.3) | 0.1 | 1.6 | |
| t-PA activity (IU/ml) | 0 | 0.5 (0.1) | 0.6 (0.1) | 0.0 | 0.2 |
| 2 | 1.3 (0.5) | 1.1 (0.4) | 0.3 | 0.6 | |
| 4 | 2.0 (0.6) | 1.7 (0.9) | 0.4 | 1.2 | |
| 8 | 3.4 (1.1) | 3.9 (1.4) | 0.3 | 1.4 | |
| Absolute forearm blood flow (ml/100 ml/min) | 0 | 3.5 (0.3) | 3.2 (0.3) | 0.3 | 0.6 |
| 2 | 11.2 (0.7) | 10.3 (1.3) | 0.9 | 3.0 | |
| 4 | 14.4 (1.8) | 12.6 (1.5) | 1.7 | 4.6 | |
| 8 | 15.7 (1.1) | 14.9 (1.5) | 0.8 | 3.4 | |
| Change in forearm blood flow (%) | 2 | 206 (20) | 240 (30) | 35 | 48 |
| 4 | 300 (39) | 300 (36) | 0 | 68 | |
| 8 | 402 (49) | 384 (58) | 17 | 76 | |