Table 2

Cardiac transplantation contraindication criteria

ALT/AST, ratio of serum alanine aminotransferase to aspartate aminotransferase; PVR, pulmonary vascular resistance; WU woods units.
Cardiac disease Irreversible pulmonary hypertension (PVR >6 WU despite standardised reversibility testing protocol)
Other diseases Active infection
Pulmonary infarction within the last 6–8 weeks
Significant chronic renal impairment with persistent creatine >2.5 or clearance <25 ml/min
Significant chronic hepatic impairment with persistent bilirubin >2.5 or ALT/AST >×2
Active or recent malignancy
Systemic diseases such as amyloidosis
Significant chronic lung disease
Significant symptomatic carotid or peripheral vascular disease
Significant coagulopathies
Recent peptic ulcer disease
Major chronic disabling disease
Diabetes with end organ damage and/or brittle diabetes
Excessive obesity (e.g. >30% over normal)
Psychosocial Active mental illness
Evidence of drug, tobacco, of alcohol abuse within the last six months refractory to expert intervention
Psychosocial instability refractory to expert intervention
Age > 65 years