Cardiac transplantation contraindication criteria
| ALT/AST, ratio of serum alanine aminotransferase to aspartate aminotransferase; PVR, pulmonary vascular resistance; WU woods units. | |
| Cardiac disease | Irreversible pulmonary hypertension (PVR >6 WU despite standardised reversibility testing protocol) |
| Other diseases | Active infection |
| Pulmonary infarction within the last 6–8 weeks | |
| Significant chronic renal impairment with persistent creatine >2.5 or clearance <25 ml/min | |
| Significant chronic hepatic impairment with persistent bilirubin >2.5 or ALT/AST >×2 | |
| Active or recent malignancy | |
| Systemic diseases such as amyloidosis | |
| Significant chronic lung disease | |
| Significant symptomatic carotid or peripheral vascular disease | |
| Significant coagulopathies | |
| Recent peptic ulcer disease | |
| Major chronic disabling disease | |
| Diabetes with end organ damage and/or brittle diabetes | |
| Excessive obesity (e.g. >30% over normal) | |
| Psychosocial | Active mental illness |
| Evidence of drug, tobacco, of alcohol abuse within the last six months refractory to expert intervention | |
| Psychosocial instability refractory to expert intervention | |
| Age | > 65 years |