Summary of case control studies linking inflammatory gene polymorphisms to myocardial infarction
| Investigated gene | Number of patients | Main findings | Authors, year |
|---|---|---|---|
| IL 1ra, interleukin 1 receptor antagonist; MI, myocardial infarction; OR, odds ratio; PECAM, platelet endothelial cell adhesion molecule; TGF, transforming growth factor; TNF, tumour necrosis factor; VNTR, variable number of tandem repeats. | |||
| *Healthy control subjects not included. †Prospective study. | |||
| TNF α | 641 men | Various polymorphisms not associated with MI | Herrmann et al, 19984 |
| TNF α and β | 148 | Various polymorphisms not associated with MI | Padovani et al, 20005 |
| TGF β1 | 563 men | Pro25 associated with MI (p<0.05) but with regional variations | Cambien et al, 19966 |
| 234 men | Leu10 associated with MI in Japanese patients (OR=3.5, p<0.0001) | Yokota et al, 20007 | |
| IL-1ra | 74 | Intron 2 VNTR alleles not associated with MI | Manzoli et al, 19998 |
| 148 | Intron 2 VNTR alleles not associated with MI | Iacoviello et al, 20009 | |
| CD14 | 178 men | –260T associated with first MI (OR=1.8, p=0.0005) | Hubaceck et al, 199910 |
| 81 men | –260T associated with first MI in Japanese (OR=3.8, p=0.004) | Shimada et al, 200011 | |
| 173* | –260T associated with MI in “low risk” patients undergoing angiography (OR=1.6, p<0.05) | Unckelbach et al, 199912 | |
| 387† men | –260T not associated with incident MI | Zee et al, 200113 | |
| P selectin | 650 men | Pro715 protective against MI (OR=0.7, p<0.02) | Herrmann et al, 199814 |
| E selectin | 650 men | Arg128 not associated with MI | Herrmann et al, 199814 |
| PECAM 1 | 1170* | Val125 not associated with MI | Gardemann et al, 200015 |