Summary of case control studies linking inflammatory gene polymorphisms to atherosclerosis
| Investigated gene | Number of patients | Main findings | Authors, year |
|---|---|---|---|
| CAD, coronary artery disease; IHD, ischaemic heart disease; IL 1, interleukin 1; MVD, multivessel coronary disease; OR, odds ratio; RR, relative risk; SVD, single vessel coronary disease. | |||
| *Healthy control subjects not included. | |||
| TNF α | 641 men | Several polymorphisms not associated with severity or extent of CAD | Herrmann et al, 19984 |
| 674 | –308A not associated with CAD | Francis et al, 199916 | |
| 700 men (autopsy) | –308A not associated with CAD | Keso et al, 200117 | |
| TNF β | 199 men | Thr26 not associated with CAD | Braun et al, 199818 |
| TGF β1 | 374 men | Several variants not associated with CAD | Cambien et al, 19966 |
| 655* | Several polymorphisms not associated with coronary artery diameter stenoses ≥30% | Syrris et al, 199819 | |
| 371* | –509T not associated with CAD | Wang et al, 199820 | |
| TGF β2 | 101 | TGF β2 variant not associated with IHD | Biggart et al, 199821 |
| IL 1 system | 674 | IL 1α (–889) and IL –1β (–511 and +3593) not associated with CAD | Francis et al, 199916 |
| 674 | IL 1ra intron 2 VNTR allele 2 associated with SVD (OR=2.8, p<0.005) but not with MVD | Francis et al, 199916 | |
| 1850 | IL 1ra +8006C (exon 2) associated with protection against restenosis | Kastrati et al, 200022 | |
| CD14 | 1053 | –159T not associated with CAD | Unckelbach et al, 199912 |
| E selectin | 97 and 99 | Arg128 and Phe554T associated with severe coronary or peripheral atherosclerosis ≤50 years (p=0.02) | Wenzel et al, 1994,23 199624 |
| 82* | Arg128 associated with ≥50% coronary stenoses (p<0.05) | Ye et al, 199925 | |
| PECAM 1 | 98 | Val125 and Asn563 associated with CAD ≤50 years (p<0.05) | Wenzel et al, 199926 |
| 2500* | Val125 associated with CAD in “low ” versus “high risk” patients (RR=1.5, p=0.035) | Gardemann et al, 200015 | |