Comparison between borderline and active myocarditis: pathological data from the endomyocardial biopsy (EMB)
| Active | Borderline | |
|---|---|---|
| Data are mean (SD). | ||
| *p = 0.04; **p = 0.004. | ||
| DCM, dilated cardiomyopathy; EMB, endomyocardial biopsy; HE, haematoxylin and eosin stain; PCR: polymerase chain reaction. | ||
| Number of patients | 26 (62%) | 16 (38%) |
| Days from onset to EMB | 40 (55) (range 1–180) | 90 (93) (range 5–335)* |
| Inflammatory infiltrate on HE | ||
| Quantification (0-3) | 1.65 (0.8) | 0.85 (0.3)** |
| Composition | ||
| Lymphomonocytes | 18 (69%) | 16 (100%) |
| Polymorphic | 8 (31%) | 0 (0%) |
| Fibrosis | ||
| Present | 18 (69%) | 11 (69%) |
| Quantification (0–3) | 1.1 (1) | 0.93 (0.7) |
| Histological aspects of DCM | 5 (19%) | 6 (37.5%) |
| Immunohistochemistry | ||
| Mainly CD43 | 11 (38%) | 6 (37.5%) |
| CD43 and CD68 | 7 (27%) | 6 (37.5%) |
| Mainly CD68 | 7 (27%) | 3 (18.7%) |
| Only CD45 | 1 (4%) | 1 (6.3%) |
| PCR positive | 6/15 (40%) | 2/8 (25%) |
| Enterovirus | 3 | 0 |
| Herpesvirus | 2 | 1 |
| Adenovirus | 0 | 1 |
| Influenza virus | 1 | 0 |
| Mumps virus | 0 | 0 |