Table 1

Characteristics of the chronic heart failure cohort (n = 1760) on 1 July 1993 by previous and current allopurinol (A) exposure

NeverRecent low dose ALong standing low dose ALong standing high dose Ap Value
2 test for association. ACE, angiotensin converting enzyme; MI, myocardial infarction; NSAIDs, non-steroidal anti-inflammatory drugs.
Number1593724847
Mean (SD) age (years)68.0 (10.7)66.1 (9.7)65.4 (10.0)65.7 (9.2)0.712
Mean (SD) time from first MI to 1993 (years)5.14 (3.81)5.72 (3.67)5.64 (3.77)6.71 (3.17)0.02
Mean (SD) number of MIs before 19932.06 (1.03)2.47 (1.07)2.02 (1.02)2.40 (1.17)0.0015
Men784 (49.2%)45 (62.5%)27 (56.3%)37 (78.7%)0.001
Women809 (50.8%)27 (37.5%)21 (43.7%)10 (21.3%)
Social deprivation
    199 (6.2%)5 (6.9%)5 (10.4%)2 (4.3%)0.54
    2223 (14.1%)17 (23.6%)8 (16.7%)5 (10.6%)
    3373 (23.5%)14 (19.4%)10 (20.8%)15 (31.9%)
    4337 (21.2%)14 (19.4%)13 (27.1%)12 (25.5%)
    5194 (12.2%)5 (6.9%)5 (10.4%)5 (10.6%)
    6/7361 (22.8%)17 (23.6%)7 (14.6%)8 (17.0%)
Diabetes102 (6.4%)5 (6.9%)0 (0.0%)2 (4.3%)0.08
Loop diuretic dose
    Low1099 (69.0%)36 (50.0%)19 (39.6%)22 (46.8%)0.001
    Medium426 (26.7%)26 (36.1%)21 (43.8%)21 (44.7%)
    High68 (4.3%)10 (13.9%)8 (16.7%)4 (8.5%)
History
    Use of NSAIDs85 (5.3%)3 (4.2%)5 (10.4%)7 (14.9%)0.018
    Use of thiazides76 (4.8%)8 (11.1%)2 (4.2%)3 (6.4%)0.11
    Respiratory illness481 (30.2%)29 (40.3%)20 (41.7%)14 (29.8%)0.11
    Renal disease175 (11.0%)6 (8.3%)5 (10.4%)5 (10.6%)0.92
    Hypertension95 (6.0%)6 (8.3%)5 (10.4%)5 (10.6%)0.30
Drugs in concurrent use
    Aspirin893 (56.1%)46 (63.9%)25 (52.1%)24 (51.1%)0.46
    Anticoagulants137 (8.6%)15 (20.8%)6 (12.5%)7 (14.9%)0.002
    ACE inhibitors573 (36.0%)39 (54.2%)22 (45.8%)20 (42.6%)0.007
    β Blockers298 (18.75%)39 (54.2%)6 (12.5%)11 (23.4%)0.49
    Nitrates1092 (68.6%)54 (75.0%)31 (64.6%)36 (76.6%)0.38
    Digoxin357 (22.45%)31 (43.1%)13 (27.1%)12 (25.5%)0.001
    K+ sparing diuretics980 (61.5%)39 (54.2%)23 (47.9%)31 (66.0%)0.14
    Antiarrhythmics65 (4.1%)7 (9.7%)1 (2.1%)1 (2.1%)0.09