Table 1

Effect of oral treatment with idebenone for six months on cardiac indices in Friedreich's ataxia

			Before treatment			After treatment
Patient number	Sex	Age (years)	LV mass index (g/m²)	IVSd thickness (mm)	Shortening fraction (%)	LV mass index (g/m²)	IVSd thickness (mm)	Shortening fraction (%)	LV mass index change (%)
Normal values are given as mean (SD).
*Left ventricular mass (g) not corrected for body surface.
†p Value associated with paired testing of left ventricular mass index before and after treatment.
F, female; IVSd thickness, interventricular septal thickness measured in diastole; LV, left ventricular; M, male.
1	F	12	218	13	60	132	10	47	−39
2	F	11	154	15	37	99	9	40	−36
3	F	22	191	21	50	125	15	37	−35
4	M	12	364	17	46	237	11	54	−35
5	F	7	165	12	44	112	11	39	−32
6	M	17	121*	12	40	85*	8	36	−30
7	F	10	230	16	47	167	13	43	−28
8	M	10	170	14	52	126	10	49	−26
9	F	13	128	16	47	95	11	49	−26
10	M	4	202	13	38	154	12	51	−24
11	M	13	212	16	37	160	13	32	−24
12	M	22	178	17	11	135	13	23	−24
13	F	29	73	11	41	56	8	31	−23
14	M	14	101	10	50	79	9	47	−22
15	M	13	201	16	40	156	14	42	−22
16	M	6	240	14	25	189	10	20	−21
17	F	12	200	17	47	160	13	57	−20
18	F	13	130	10	32	105	9	32	−19
19	M	12	97	12	40	79	9	35	−18
20	M	31	113	14	26	94	12	51	−17
21	F	13	78	9	37	67	8	50	−14
22	M	8	286	16	51	245	17	51	−14
23	F	19	141	15	44	123	12	59	−13
24	F	12	146	12	45	131	11	39	−11
25	M	21	87	10	41	80	11	39	−8
26	F	20	130	12	47	119	12	47	−8
27	F	18	378	30	43	350	30	44	−7
28	M	17	113	10	37	106	10	47	−6
29	M	17	143*	9	31	137*	9	31	−5
30	M	10	248	15	25	237	10	30	−4
31l	M	14	177	12	38	174	9	37	−1
32	M	18	131	12	34	132	11	36	+1
33	F	13	169	14	25	172	16	37	+2
34	F	21	121	10	47	128	15	43	+6
35	M	17	89	9	30	98	8	30	+10
36	M	9	358	18	23	392	17	14	+10
37	F	21	77	7	42	91	9	38	+18
38	F	15	93	11	45	109	10	37	+18

n=38; M/F ratio 1:1			Normal value: 80 (20) g/m²		Normal value: 33 (3)%				−14 (14) (p<0.001)†