Influence of renin-angiotensin-aldosterone system (RAAS) genes on phenotype in family members with the MyBP-C mutation compared with the family group with no pro-LVH polymorphisms (n=10)
| RAAS gene | Genotype | p Value analysis | LV mass (g) | IVST (mm) | Pathological ECG |
|---|---|---|---|---|---|
| *Control group for statistical comparisons. | |||||
| †General linear model (LV mass, ISVT) or logistic regression analysis (ECG abnormality) controlling for age, sex, and the presence of hypertension. | |||||
| No pro-LVH genes present* (n=10) | 189.9 (47.5) | 11.5 (1.9) | 0 | ||
| ACE (n=6) | DD | 302.8 (58.7) | 15.2 (4.8) | 3 (50%) | |
| Univariate | 0.001 | 0.049 | 0.04 | ||
| Multivariate† | 0.04 | ns | ns | ||
| AGT (n=6) | CC | 334.5 (127.4) | 18.6 (6.8) | 3 (50%) | |
| Univariate | 0.005 | 0.007 | 0.04 | ||
| Multivariate† | 0.02 | 0.04 | ns | ||
| AGTR (n=1) | CC | 547.5 | 26 | 1 (100%) | |
| Univariate | – | – | 0.09 | ||
| Multivariate† | 0.001 | 0.001 | ns | ||
| CMA (n=6) | AA | 365.6 (142.0) | 20.3 (8.4) | 4 (67%) | |
| Univariate | 0.003 | 0.006 | 0.008 | ||
| Multivariate† | 0.06 | 0.06 | ns | ||
| CYP11B2 (n=4) | CC | 323.6 (110.8) | 15.5 (6.3) | 4 (100%) | |
| Univariate | 0.007 | 0.085 | 0.001 | ||
| Multivariate† | 0.01 | 0.007 | ns | ||