Urinary catecholamine excretion, signs of ischaemia, and heart rate variability in patients with an ambulatory ECG registration suitable for heart rate variability measurements and with results from all urine catecholamine measurements at baseline, excluding those treated with digoxin or with left bundle branch block
| No CV death or MI (n=503) | CV death (n=23) | p Value* | Non-fatal MI (n=25) | |
|---|---|---|---|---|
| Urinary excretion of catecholamines was measured in nmol/l and adjusted for creatinine excretion. *Comparison between patients suffering CV death and those without CV death or MI. Mann-Whitney U test and t test (catecholamines) on log transformed values. | ||||
| HF, high frequency power; LF, low frequency power; VLF, very low frequency power. | ||||
| Adrenaline (nmol/mmol creatinine), mean (SD) | ||||
| Daytime | 4.11 (3.42) | 3.56 (2.23) | 3.78 (2.07) | |
| Night time | 1.17 (1.89) | 1.60 (2.37) | 0.87 (0.66) | |
| Calculated 24 hour mean | 3.14 (2.74) | 2.91 (1.91) | 2.81 (1.57) | |
| Noradrenaline (nmol/mmol creatinine), mean(SD) | ||||
| Daytime | 35.11 (13.38) | 31.91 (13.62) | 32.96 (11.63) | |
| Night time | 18.46 (8.18) | 16.29 (8.84) | 17.46 (7.75) | |
| Calculated 24 hour mean | 29.56 (11.03) | 26.70 (11.61) | 27.79 (9.69) | |
| Ambulatory ECG results, median (first and third quartiles) | ||||
| Number of epochs with ST segment depression | 1 (0;7) | 5 (1;19) | 0.016 | 4 (0;9) |
| Duration of ST segment depression (min) | 5 (0;40) | 24 (2;227) | 0.009 | 10 (0;58) |
| Minimal heart rate (beats/min) | 47 (44;52) | 52 (48;58) | 0.002 | 48 (46;52) |
| Heart rate variability, median (first and third quartiles) | ||||
| Mean RR interval (ms) | 845 (769;924) | 804 (741;903) | 865 (799;893) | |
| Total power (ms2) | 1234 (799;1926) | 958 (447;1288) | 0.007 | 1225 (657;1666) |
| VLF (ms2) | 613 (399;876) | 499 (254;843) | 0.057 | 580 (406;849) |
| LF (ms2) | 415 (244;650) | 241 (95;449) | 0.003 | 391 (221;562) |
| HF (ms2) | 172 (99;301) | 81 (59;174) | <0.001 | 137 (108;240) |
| LF:HF ratio | 2.3 (1.7;3.2) | 2.3 (1.7;3.4) | 2.4 (1.6;3.0) | |
| Normalised VLF | 0.47 (0.42;0.52) | 0.53 (0.49;0.58) | <0.001 | 0.48 (0.44;0.53) |
| Normalised LF | 0.35 (0.30;0.39) | 0.30 (0.25;0.37) | 0.004 | 0.34 (0.31;0.36) |
| Normalised HF | 0.17 (0.14;0.21) | 0.16 (0.12;0.19) | 0.088 | 0.17 (0.14;0.21) |