Table 3

Urinary catecholamine excretion, signs of ischaemia, and heart rate variability in patients with an ambulatory ECG registration suitable for heart rate variability measurements and with results from all urine catecholamine measurements at baseline, excluding those treated with digoxin or with left bundle branch block

No CV death or MI (n=503)CV death (n=23)p Value*Non-fatal MI (n=25)
Urinary excretion of catecholamines was measured in nmol/l and adjusted for creatinine excretion. *Comparison between patients suffering CV death and those without CV death or MI. Mann-Whitney U test and t test (catecholamines) on log transformed values.
HF, high frequency power; LF, low frequency power; VLF, very low frequency power.
Adrenaline (nmol/mmol creatinine), mean (SD)
    Daytime4.11 (3.42)3.56 (2.23)3.78 (2.07)
    Night time1.17 (1.89)1.60 (2.37)0.87 (0.66)
    Calculated 24 hour mean3.14 (2.74)2.91 (1.91)2.81 (1.57)
Noradrenaline (nmol/mmol creatinine), mean(SD)
    Daytime35.11 (13.38)31.91 (13.62)32.96 (11.63)
    Night time18.46 (8.18)16.29 (8.84)17.46 (7.75)
    Calculated 24 hour mean29.56 (11.03)26.70 (11.61)27.79 (9.69)
Ambulatory ECG results, median (first and third quartiles)
    Number of epochs with ST segment depression1 (0;7)5 (1;19)0.0164 (0;9)
    Duration of ST segment depression (min)5 (0;40)24 (2;227)0.00910 (0;58)
    Minimal heart rate (beats/min)47 (44;52)52 (48;58)0.00248 (46;52)
Heart rate variability, median (first and third quartiles)
    Mean RR interval (ms)845 (769;924)804 (741;903)865 (799;893)
    Total power (ms2)1234 (799;1926)958 (447;1288)0.0071225 (657;1666)
    VLF (ms2)613 (399;876)499 (254;843)0.057580 (406;849)
    LF (ms2)415 (244;650)241 (95;449)0.003391 (221;562)
    HF (ms2)172 (99;301)81 (59;174)<0.001137 (108;240)
    LF:HF ratio2.3 (1.7;3.2)2.3 (1.7;3.4)2.4 (1.6;3.0)
    Normalised VLF0.47 (0.42;0.52)0.53 (0.49;0.58)<0.0010.48 (0.44;0.53)
    Normalised LF0.35 (0.30;0.39)0.30 (0.25;0.37)0.0040.34 (0.31;0.36)
    Normalised HF0.17 (0.14;0.21)0.16 (0.12;0.19)0.0880.17 (0.14;0.21)