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β-Endorphin, adrenocorticotropic hormone, cortisol and catecholamines during aerobic and anaerobic exercise

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Summary

Twelve non-specifically trained volunteers (aged 26.5 years, SD 3.6) performed exhausting incremental graded exercise (ST) and 1-min anaerobic cycle ergometer exercise (AnT) at 2-h intervals for the purpose of investigating β-endorphin (β-E) behaviour dependent on exercise intensity and anaerobic metabolism. In order to determine [β-E], adrenocorticotropic hormone [ACTH], cortisol [C], adrenaline [A] and noradrenaline [NA] concentrations, venous blood samples were collected prior and subsequent to exercise until the 20th min of the recovery period, as well as in ST before and after exceeding the individual anaerobic threshold (THan, i). Before, during and after ST, lactate concentration, heart rate and perceived degree of exertion were also determined; after AnT maximum lactate concentration was measured. Both types of exercise led to significant increases in [β-E], [ACTH], [A] and [NA], with levels of [β-E] and [ACTH] approximately twice as high after ST as after AnT. The [C] increased significantly only after ST. During ST significant changes in [β-E] and [ACTH] were measured only after exceeding THan, i. At all measuring times before and after ST and AnT both hormones correlated positively. In AnT the increases of [β-E] and [A] demonstrated a correlation (r= 0.65; P< 0.05). Both in AnT and ST there was a relationship between the maximum concentrations of β-E and lactate (r=0.63 and 0.71; each P<0.05). We therefore conclude that physical exercise with increasing or mostly anaerobic components leads to an increase in [β-E], the extent correlating with the degree of lactate concentration. The similar behaviour of [β-E] and [A] after AnT might suggest mutual influences of endogenous opioids and catecholamines.

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References

  • Allan EH, Green IC, Titheradge MA (1983) The stimulation of glycogenolysis and gluconeogenesis in isolated hepatocytes by opioid peptides. Biochem J 216:507–510

    Google Scholar 

  • Berkenbosch F, Vermes I, Binnekade R (1981) Beta-adrenergic stimulation induces an increase of the plasma levels of immunoreactive alpha-MSH, beta-endorphin, ACTH and of corticosterone. Life Sci 29:2249–2256

    Google Scholar 

  • Borg GAV (1973) Perceived exertion: a note on “history” and methods. Med Sci Sports 5:90–93

    Google Scholar 

  • Brooks S, Burrin J, Cheetham ME, Hall GM, Yeo T, Williams C (1988) The responses of the catecholamines and β-endorphin to brief maximal exercise in man. Eur J Appl Physiol 57:230–234

    Google Scholar 

  • Buono MJ, Yeager JE, Hodgdon JA (1986) Plasma adrenocorticotropin and cortisol responses to brief high-intensity exercise in humans. J Appl Physiol 61:1337–1339

    Google Scholar 

  • Chavkin C, Cox BM, Goldstein A (1979) Stereo-specific opiate binding in the bovine adrenal medulla. Mol Pharmacol 15:751–753

    Google Scholar 

  • Da Prada M, Zürcher G (1976) Simultaneous radioenzymatic determination of plasma and tissue adrenaline, noradrenaline, and dopamine within the femtomole range. Life Sci 19:1161–1174

    Google Scholar 

  • Dearman J, Francis KT (1983) Plasma levels of catecholamines, cortisol, and β-endorphins in male athletes after running 26.2. 6, and 2 miles. J Sport Med 23:30–38

    Google Scholar 

  • De Meirleir K, Naaktgeboren N, Steirteghem V, Gorus F, Albrecht J, Block P (1986) Beta-endorphin and ACTH levels in peripheral blood during and after aerobic and anaerobic exercise. Eur J Appl Physiol 55:5–8

    Google Scholar 

  • Donevan RH, Andrew GM (1987) Plasma β-endorphin immunoreactivity during graded cycle ergometry. Med Sci Sports Exerc 19:229–233

    Google Scholar 

  • Estilo AE, Cottrell JE (1982) Hemodynamic and catecholamine changes after administration of naloxone. Anesth Analg 61:349–353

    Google Scholar 

  • Farrell PA, Gates WK, Morgan WP, Maksud MG (1982) Increases in plasma β-endorphin/β-lipotropin immunoreactivity after treadmill running in humans. J Appl Physiol 52:1245–1249

    Google Scholar 

  • Farrell PA, Garthwaite TL, Gustafson AB (1983) Plasma adrenocorticotropin and cortisol responses to submaximal and exhaustive exercise. J Appl Physiol 55:1441–1444

    Google Scholar 

  • Fraioli F, Moretti C, Paolucci D, Alicicco E, Crescenzi F, Fortunio G (1980) Physical exercise stimulates marked concomitant release of β-endorphin and ACTH in peripheral blood in man. Experientia 36:987–989

    Google Scholar 

  • Goldfarb AH, Hatfield BD, Sforzo GA, Flynn MG (1987) Serum β-endorphin levels during a graded exercise test to exhaustion. Med Sci Sports Exerc 19:78–82

    Google Scholar 

  • Guillemin R, Vargo T, Rossier J, Minick S, Ling N, Rivier C, Yair W, Bloom F (1977) β-Endorphin and adrenocorticotropin are secreted concomitantly by the pituitary gland. Science 197:1362–1369

    Google Scholar 

  • Hodgkinson SC, Allolio B, Landon J, Lowry PhJ (1984) Development of a non-extracted “two-site” immunoradiometric assay for corticotropin utilizing extreme amino- and carboxy-terminally directed antibodies. Biochem J 218:703–711

    Google Scholar 

  • Hohorst HJ (1962) L-(+)-Lactat, Bestimmung mit Lactatdehydrogenase und DPN. In: Bergmeyer HU (ed) Methoden der enzymatischen Analyse. Verlag Chemie, Weinheim

    Google Scholar 

  • Hughes J, Smith TW, Kosterlitz HW, Fothergill LA, Morgan MA, Morris HR (1975) Identification of two related pentapeptides from the brain with potent opiate against activity. Nature 258:577

    Google Scholar 

  • Kraemer WJ, Fleck SJ, Callister R, Shealy M, Dudley GA, Maresh CM, Marchitelli L, Cruthirds C, Murray T, Falkel JE (1989) Training responses of plasma beta-endorphin, adrenocorticotropin, and cortisol. Med Sci Sports Exerc 21:146–153

    Google Scholar 

  • Krieger DT (1982) Endorphins and enkephalins. Dis Mon 28:153

    Google Scholar 

  • Li CH (1977) β-Endorphin: a pituitary peptide with potent morphine-like reactivity. Arch Biochem 183:592–604

    Google Scholar 

  • Mains RE, Eipper BA, Ling N (1977) Common precursor to corticotropins and endorphins. Proc Natl Acad Sci USA 74:3014–3018

    Google Scholar 

  • Mannelli M, Maggi M, De Feo ML, Cuomo S, Delitala G, Giusti G, Serio M (1984) Effects of naloxone on catecholamine plasma levels in adult men. A dose-response study. Acta Endocrinol 106:357–361

    Google Scholar 

  • Matsumura M, Fukushima T, Saito H, Saito S (1984) In vivo and in vitro effects of β-endorphin on glucose metabolism in the rat. Horm Metab Res 16:27–31

    Google Scholar 

  • McMurray RG, Forsythe WA, Mar MH, Hardy CJ (1987) Exercise intensity-related responses of β-endorphin and catecholamines. Med Sci Sports Exerc 19:570–574

    Google Scholar 

  • Mougin C, Baulay A, Henriet MT, Haton D, Jacquier MC, Turnill D, Berthelay S, Gaillard RC (1987) Assessment of plasma opioid peptides, β-endorphin and met-enkephalin at the end of an international nordic ski race. Eur J Appl Physiol 56:281–286

    Google Scholar 

  • Rahkila P, Hakala E, Salminen K, Laatikainen T (1987) Response of plasma endorphins to running exercises in male and female endurance athletes. Med Sci Sports Exerc 19:451–455

    Google Scholar 

  • Rolleri E, Zannino M, Orlandini S, Malvano R (1976) Direct radioimmunoassay of plasma cortisol. Clin Chim Acta 66:319–330

    Google Scholar 

  • Schwarz L, Kindermann W (1989) β-endorphin, catecholamines, and cortisol during exhaustive endurance exercise. Int J Sports Med 10:324–328

    Google Scholar 

  • Stegmann H, Kindermann W, Schnabel A (1981) Lactate kinetics and individual anaerobic threshold. Int J Sports Med 2:160–165

    Google Scholar 

  • Sutton J, Coleman MT, Casey JH (1974) Adrenocortical contribution to serum androgens during physical exercise. Med Sci Sports 6:72

    Google Scholar 

  • Vuolteenaho O, Leppaluoto J, Vakkuri O, Karppinen J, Höyhtyä M, Ling N (1981) Development and validation of a radioimmunoassay for beta-endorphin-related peptides. Acta Physiol Scand 112:313–321

    Google Scholar 

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Schwarz, L., Kindermann, W. β-Endorphin, adrenocorticotropic hormone, cortisol and catecholamines during aerobic and anaerobic exercise. Eur J Appl Physiol 61, 165–171 (1990). https://doi.org/10.1007/BF00357593

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