Skip to main content

Advertisement

Log in

Childhood adversities, adult risk factors and depressiveness

A population study

  • Original Investigation
  • Published:
Social Psychiatry and Psychiatric Epidemiology Aims and scope Submit manuscript

Abstract

Objective

Childhood adversities have been associated with adulthood depressiveness, but the contribution of adult risk factors is seldom described. We examined whether adult risk factors lie on the pathway from childhood adversity to adult depressiveness (pathway hypothesis) or whether the association depends on life events (vulnerability hypothesis).

Method

Among 21,101 randomly sampled working-aged respondents [the Health and Social Support in Finland (HeSSup) Study], the hypotheses were tested with logistic regression analysis models studying the associations between Beck Depression Inventory (BDI)-assessed depressiveness and self-reported childhood adversities alone and in combination with recent adverse events.

Results

Childhood adversities were consistently associated with depressiveness (women, age-adjusted odds ratio 3.1, 95% confidence intervals 2.6–3.7; men, 2.6, 2.1–3.3), although the risks were decreased by more than 30% after adjustments for adult risk factors such as living alone, education, alcohol consumption, social support and negative affectivity. Childhood adversities combined with recent life events were associated with depressiveness in an additive manner. Women with childhood adversities and recent person-independent events especially had increased vulnerability for depressiveness.

Conclusions

The childhood adversity–depressiveness associations were partly mediated by adult risk factors, supporting a pathway from childhood adversities to depressiveness through adult risk factors. Increased vulnerability for depressiveness was found among respondents with childhood adversities in combination with recent death/illness events. The findings emphasize the importance of early risk factors when identifying persons at risk of depression.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Schwartz JE, Friedman HS, Tucker JS, Tomlinson-Keasey C, Wingard DL, Criqui MH (1995) Sociodemographic and psychosocial factors in childhood as predictors of adult mortality. Am J Public Health 85:1237–1245

    PubMed  Google Scholar 

  2. Felitti VJ, Anda RF, Nordenberg D, Williamson DF, Spitz AM, Edwards V, Koss MP, Marks JS (1998) Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. Am J Prev Med 14:245–258

    Article  PubMed  Google Scholar 

  3. Weitoft GR, Hjern A, Haglund B, Rosén M (2003) Mortality, severe morbidity, and injury in children living with single parents in Sweden: a population-based study. Lancet 361:289–295

    Article  PubMed  Google Scholar 

  4. Batten SV, Aslan M, Maciejewski PK, Mazure CM (2004) Childhood maltreatment as a risk factor for adult cardiovascular disease and depression. J Clin Psychiatry 65:249–254

    PubMed  Google Scholar 

  5. Kessler RC, Davis CG, Kendler KS (1997) Childhood adversity and adult psychiatric disorder in the US National Comorbidity Survey. Psychol Med 27:1101–1119

    Article  PubMed  Google Scholar 

  6. Kivelä SL, Luukinen H, Koski K, Viramo P, Pahkala K (1998) Early loss of mother or father predicts depression in old age. Int J Geriatr Psychiatry 13:527–530

    Article  PubMed  Google Scholar 

  7. Gilman SE, Kawachi I, Fitzmaurice GM, Buka L (2003) Socio-economic status, family disruption and residential stability in childhood: relation to onset, recurrence and remission of major depression. Psychol Med 33:1341–1355

    Article  PubMed  Google Scholar 

  8. Mazure CM (1998) Life stressors as risk factors in depression. Clin Psychol Sci Pract 5:291–313

    Google Scholar 

  9. Kendler KS, Karkowski LM, Prescott CA (1999) Causal relationships between stressful life events and the onset of major depression. Am J Psychiatry 156:837–841

    PubMed  Google Scholar 

  10. Rutter M, Silberg J (2002) Gene–environment interplay in relation to emotional and behavioral disturbance. Annu Rev Psychol 53:463–490

    Article  PubMed  Google Scholar 

  11. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R (2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301:386–389

    Article  PubMed  Google Scholar 

  12. Kendler KS, Gardner CO, Prescott CA (2002) Toward a comprehensive developmental model for major depression in women. Am J Psychiatry 159:1133–1145

    Article  PubMed  Google Scholar 

  13. Poulton R, Caspi A, Milne BJ, Thomson WM, Taylor A, Sears MR, Moffitt TE (2002) Association between children's experience of socioeconomic disadvantage and adult health: a life-course study. Lancet 360:1640–1645

    Article  PubMed  Google Scholar 

  14. Cairney J, Boyle M, Offord DR, Racine Y (2003) Stress, social support and depression in single and married mothers. Soc Psychiatry Psychiatr Epidemiol 38:442–449

    Article  PubMed  Google Scholar 

  15. Kessler RC (1997) The effects of stressful life events on depression. Annu Rev Psychol 48:191–214

    Article  PubMed  Google Scholar 

  16. Hemingway H, Marmot M (1999) Psychosocial factors in the aetiology and prognosis of coronary heart disease: systematic review of prospective cohort studies. BMJ 318:1460–1467

    PubMed  Google Scholar 

  17. Kivimäki M, Vahtera J, Elovainio M, Lillrank B, Kevin MV (2002) Death or illness of a family member, violence, interpersonal conflict, and financial difficulties as predictors of sickness absence: longitudinal cohort study on psychological and behavioral links. Psychosom Med 64:817–825

    Article  PubMed  Google Scholar 

  18. Heim C, Nemeroff CB (2001) The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol Psychiatry 49:1023–1039

    Article  PubMed  Google Scholar 

  19. McEwen BS (1998) Protective and damaging effects of stress mediators. N Engl J Med 338:171–179

    Article  PubMed  Google Scholar 

  20. Korkeila K, Suominen S, Ahvenainen J, Ojanlatva A, Rautava P, Helenius H, Koskenvuo M (2001) Non-response and related factors in a nation-wide health survey. Eur J Epidemiol 17:991–999

    Article  PubMed  Google Scholar 

  21. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J (1961) An inventory for measuring depression. Arch Gen Psychiatry 4:53–63

    Google Scholar 

  22. Beck AT, Steer RA, Garbin MG (1988) Psychometric properties of the Beck Depression Inventory: twenty-five years of evaluation. Clin Psychol Rev 8:77–100

    Article  Google Scholar 

  23. Korkeila K, Kivelä S-L, Suominen S, Sundell J, Vahtera J, Kivimäki M, Helenius H, Koskenvuo M (2004) Childhood adversities, parent–child relationships and dispositional optimism in adulthood. Soc Psychiatry Psychiatr Epidemiol 39:286–292

    Article  PubMed  Google Scholar 

  24. Romanov K, Varjonen J, Kaprio J, Koskenvuo M (2003) Life events and depressiveness—the effect of adjustment for psychosocial factors, somatic health and genetic liability. Acta Psychiatr Scand 107:25–33

    Article  PubMed  Google Scholar 

  25. Sarason IG, Sarason BR, Shearin EN, Pierce GR (1987) A brief measure of social support: practical and theoretical implications. J Soc Pers Relatsh 4:497–510

    Google Scholar 

  26. Seppä K (1998) Alkoholiongelman varhaistoteaminen. [Early identification of an alcohol problem]. In: Salaspuro M, Kiianmaa K, Seppä K (eds) Päihdelääketiede [Addiction medicine]. Kustannus Oy Duodecim, Helsinki, Finland, pp 54–60

    Google Scholar 

  27. Reeder LG, Schrama PG, Dirken JM (1973) Stress and cardiovascular health: an international cooperative study. I. Soc Sci Med 7:573–584

    Article  PubMed  Google Scholar 

  28. Agresti A (2000) Categorical data analysis, 2nd edn. Wiley, New York, pp 182–195

    Google Scholar 

  29. Baron RM, Kenny DA (1986) The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol 51:1173–1182

    Article  PubMed  Google Scholar 

  30. Rutter M (1985) Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder. Br J Psychiatry 147:598–611

    PubMed  Google Scholar 

  31. Kendler KS, Hettema JM, Butera F, Gardner CO, Prescott CA (2003) Life event dimensions of loss, humiliation, entrapment, and danger in the prediction of onsets of major depression and generalized anxiety. Arch Gen Psychiatry 60:789–796

    Article  PubMed  Google Scholar 

  32. Maciejewski PK, Prigerson HG, Mazure CM (2001) Sex differences in event-related risk for major depression. Psychol Med 31:593–604

    Article  PubMed  Google Scholar 

  33. Lasa L, Ayuso-Mateos JL, Vazquez-Barquero JL, Diez-Manrique FJ, Dowrick CF (2000) The use of the Beck Depression Inventory to screen for depression in the general population: a preliminary analysis. J Affect Disord 57:261–265

    Article  PubMed  Google Scholar 

  34. Judd LL, Akiskal HS, Zeller PJ, Paulus M, Leon AC, Maser JD, Endicott J, Coryell W, Kunovac JL, Mueller TI, Rice JP, Keller MB (2000) Psychosocial disability during the long-term course of unipolar major depressive disorder. Arch Gen Psychiatry 57:375–380

    Article  PubMed  Google Scholar 

  35. Murray CJL, Lopez AD (1996) The global burden of disease. A comprehensive assessment of mortality and disability from disease, injuries and risk factors in 1990 and projected to 2020. Harvard University Press, Cambridge, MA

    Google Scholar 

Download references

Acknowledgements

The HeSSup Study has been supported by grants from the Finnish Academy (project 41290), the Yrjö Jahnsson Foundation and the Emil Aaltonen Foundation. Katariina Korkeila was supported by grants from the Yrjö Jahnsson Foundation (grant 5061) and Turku University Hospital Research Fund (grant 8171/13529/03), Jussi Vahtera and Mika Kivimäki by grants from the Finnish Work Environment Fund (grants 101190 and 103432) and the Finnish Academy (projects 77560 and 105195).

We wish to acknowledge Jari Sundell, MSc, and Sami Saarelainen, student of statistics, for their assistance with data analyses. We also thank Jacqueline Välimäki, MA, and lecturer, Department of English Translation Studies, University of Turku, Finland, for checking the English language of the manuscript.

The HeSSup Study Group consists of the following researchers: Elovainio Marko, Franck Jaana, Helenius Hans, Immonen-Räihä Pirjo, Jalava-Broman Jaana, Jokinen Kirsi, Kivimäki Mika, Korkeila Jyrki, Korkeila Katariina, Koskenvuo Markku, Lillberg Kirsi, Lintula Hanna, Mattila Kari, Ojanlatva Ansa, Paljärvi Tapio, Rautava Päivi, Sillanmäki Lauri, Sumanen Markku, Suominen Sakari, Vahtera Jussi, Vainiomäki Paula, Virtanen Pekka, Volanen Salla-Maarit.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Katariina Korkeila MD, PhD.

Additional information

Location of work: Dept. of Family Medicine and Dept. of Public Health, University of Turku, Finland.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Korkeila, K., Korkeila, J., Vahtera, J. et al. Childhood adversities, adult risk factors and depressiveness. Soc Psychiat Epidemiol 40, 700–706 (2005). https://doi.org/10.1007/s00127-005-0969-x

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00127-005-0969-x

Keywords

Navigation