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Diagnostic accuracy and variability of three semi-quantitative methods for assessing right ventricular systolic function from cardiac MRI in patients with acquired heart disease

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Abstract

Objectives

To evaluate the diagnostic accuracy and variability of 3 semi-quantitative (SQt) methods for assessing right ventricular (RV) systolic function from cardiac MRI in patients with acquired heart disease: tricuspid annular plane systolic excursion (TAPSE), RV fractional-shortening (RVFS) and RV fractional area change (RVFAC).

Methods

Sixty consecutive patients were enrolled. Reference RV ejection fraction (RVEF) was determined from short axis cine sequences. TAPSE, RVFS and RVFAC were measured on a 4-chamber cine sequence. All SQt analyses were performed twice by 3 observers with various degrees of training in cardiac MRI. Correlation with RVEF, intra- and inter-observer variability, and receiver operating characteristic (ROC) curve analysis were performed for each SQt method.

Results

Correlation between RVFAC and RVEF was good for all observers and did not depend on previous cardiac MRI experience (R range = 0.716–0.741). Conversely, RVFS (R range = 0.534–0.720) and TAPSE (R range = 0.482–0.646) correlated less with RVEF and depended on previous experience. Intra- and inter-observer variability was much lower for RVFAC than for RVFS and TAPSE. ROC analysis demonstrated that RVFAC <41% could predict a RVEF <45% with 90% sensitivity and 94% specificity.

Conclusions

RVFAC appears to be more accurate and reproducible than RVFS and TAPSE for SQt assessment of RV function by cardiac MRI.

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Acknowledgment

The authors are grateful to Alexandre Klimoff and Agnes Malgouyres (Siemens France) who provided us with the Argus segmentation software used in this study.

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Authors and Affiliations

  1. Department of Radiology, University Hospital of Rouen, 1 rue de Germont, 76031, Rouen Cedex, France

    Jérôme Caudron, Jeannette Fares, Pierre-Hugues Vivier, Valentin Lefebvre & Jean-Nicolas Dacher

  2. Department of Cardiology, University Hospital of Rouen, Rouen, France

    Jeannette Fares

  3. INSERM U644, University of Rouen, Rouen, France

    Jérôme Caudron, Jeannette Fares, Pierre-Hugues Vivier, Valentin Lefebvre & Jean-Nicolas Dacher

  4. LITIS EA4108, University of Rouen, Rouen, France

    Caroline Petitjean

Authors
  1. Jérôme Caudron
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  2. Jeannette Fares
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  3. Pierre-Hugues Vivier
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  4. Valentin Lefebvre
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Correspondence to Jérôme Caudron.

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Caudron, J., Fares, J., Vivier, PH. et al. Diagnostic accuracy and variability of three semi-quantitative methods for assessing right ventricular systolic function from cardiac MRI in patients with acquired heart disease. Eur Radiol 21, 2111–2120 (2011). https://doi.org/10.1007/s00330-011-2152-0

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  • DOI: https://doi.org/10.1007/s00330-011-2152-0

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