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Role of myocardial interstitial edema in conduction disturbances in acute myocarditis

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Abstract

The presence of myocardial interstitial edema in acute myocarditis (AM) leads to thickening of the ventricular wall, and conduction disturbances, such as complete atrioventricular block (CAV), also frequently develop. This study was undertaken in order to clarify the relationship between conduction disturbances and myocardial interstitial edema in AM. The subjects comprised 50 patients with acute lymphocytic myocarditis. Based on the results of echocardiographic examinations during the acute stage, the patients were divided into a hypertrophy group (n = 29) in which the sum of the thickness of the interventricular septum and left ventricular (LV) posterior wall was ≥24 mm, and a non-hypertrophy group (n = 21) in which the sum of these parameters was <24 mm. Right ventricular endomyocardial biopsies were performed in the acute stage and the degree of interstitial edema was scored histologically. Left ventricular wall thickness and QRS duration in the acute stage were 27.7 ± 3.6 mm and 124.1 ± 29.6 ms, respectively, in the hypertrophy group, and 19.9 ± 2.4 mm (P < 0.001) and 98.6 ± 21.7 ms (P < 0.01) in the non-hypertrophy group. Complete atrioventricular block was found in 13 of 29 cases (45%) in the hypertrophy group and two of 21 cases (10%) in the non-hypertrophy group (P < 0.01). Myocardial interstitial edema was scored at 1.3 ± 0.8 points in the hypertrophy group and 0.8 ± 0.6 points in the non-hypertrophy group (P < 0.05). Left ventricular wall thickness and QRS duration in the convalescent stage decreased to 21.1 ± 2.6 mm (P < 0.0001) and 97.1 ± 17.4 ms (P < 0.01) in the hypertrophy group, respectively. Only one case (4%) in the hypertrophy group continued to show CAV during the convalescent stage (P < 0.05). The results of this study suggest that myocardial interstitial edema is implicated in the conduction disturbances that occur in AM.

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Authors and Affiliations

  1. Division of Cardiology, Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Aichi, 470-1192, Japan

    Shin-ichiro Morimoto, Shigeru Kato, Shinya Hiramitsu, Akihisa Uemura, Masatsugu Ohtsuki, Yasuchika Kato, Atsushi Sugiura, Kenji Miyagishima & Hitoshi Hishida

  2. Cardiovascular Center, Nagoya Dai-ni Red Cross Hospital, Nagoya, Aichi, Japan

    Yukihiko Yoshida

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  1. Shin-ichiro Morimoto
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  2. Shigeru Kato
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  3. Shinya Hiramitsu
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  4. Akihisa Uemura
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  5. Masatsugu Ohtsuki
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  6. Yasuchika Kato
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  7. Atsushi Sugiura
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  8. Kenji Miyagishima
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  9. Yukihiko Yoshida
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  10. Hitoshi Hishida
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Correspondence to Shin-ichiro Morimoto.

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Morimoto, Si., Kato, S., Hiramitsu, S. et al. Role of myocardial interstitial edema in conduction disturbances in acute myocarditis. Heart Vessels 21, 356–360 (2006). https://doi.org/10.1007/s00380-006-0922-4

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