Elsevier

Annals of Vascular Surgery

Volume 11, Issue 5, September 1997, Pages 540-545
Annals of Vascular Surgery

Basic Science
Inflammation and Cytokine Signaling in Aneurysms

https://doi.org/10.1007/s100169900088Get rights and content

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References (36)

  • RW Busuttil et al.

    Collage-nase activity of the human aorta: A comparison of patients with and without aortic aneurysms

    Arch Surg

    (1980)
  • N Vine et al.

    Metalloproteinases in degenerative aortic disease

    Clinical Science

    (1991)
  • KM Newman et al.

    Identification of matrix metalloproteinases 3 (stromelysin-1) and 9 (gelatinase B) in abdominal aortic aneurysm

    Arterioscler Thromb

    (1994)
  • MD Tilson et al.

    Tensile strength and collagen in abdominal aortic aneurysm disease

  • AE Koch et al.

    Human abdominal aortic aneurysms: Immunophentypic analysis suggesting an immune-mediated response

    Am J Pathol

    (1990)
  • H Yanagi et al.

    Production of tissue collagenase (matrix metalloproteinase 1) by human aortic smooth muscle cells in response to platelet-derived growth factor

    Atherosclerosis

    (1992)
  • GL Faggioli et al.

    Parietal inflammatory infiltrate in peripheral aneurysms of atherosclerotic ori gin

    J Cardiovasc Surg

    (1992)
  • CH Evans et al.

    Inducible synthesis of collagenase and other neutral metalloproteinases by cells of aortic origin

    J Surg Res

    (1991)
  • Cited by (23)

    • CT signal heterogeneity of abdominal aortic aneurysm as a possible predictive biomarker for expansion

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      However, some aneurysms rupture at a smaller size [5–7], and many larger aneurysms grow to a considerable size without rupture [8]. Furthermore, patients who are in need of more frequent screening and early intervention need to be identified, and strategies for testing new medical therapies are required [9–12]. Apart from baseline AAA size, it is critical to develop non-invasive imaging techniques to detect characteristics predicting significant aneurysm growth.

    • Cleaved high molecular weight kininogen, a novel factor in the regulation of matrix metalloproteinases in vascular smooth muscle cells

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      Furthermore, several investigators have found elevated levels of inflammatory cells and cytokines in aneurysmatic tissues, including IL-1α[16]. Hence, it has been hypothesized that cytokine stimulation may trigger increased production of MMPs by inflammatory and smooth muscle cells within the aortic wall [17]. Stimulation of human VSMCs with IL-1α has been demonstrated to enhance release of both MMP-9 and MMP-2 into the culture media [14].

    • Whole Genome-expression Profiling Reveals a Role for Immune and Inflammatory Response in Abdominal Aortic Aneurysm Rupture

      2009, European Journal of Vascular and Endovascular Surgery
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      The trigger for the recruitment of inflammatory and immune cells is not yet known, but may include the increased local production of chemotactic cytokines such as IL-8, MCP-1 and RANTES (regulated on activation normal T-cell expressed and secreted).26 Human and experimental AAA tissues have also been shown to produce abundant amounts of prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6).11,13,27,28 The contributions of various components of the immune and inflammatory system have also been tested in animal models of AAA.

    • A review of biological factors implicated in abdominal aortic aneurysm rupture

      2005, European Journal of Vascular and Endovascular Surgery
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      It is likely that inflammatory cells release a cascade of pro-inflammatory cytokines that results in the activation of proteolytic enzymes.108 Human and experimental AAA tissues have been shown to produce abundant amounts of prostaglandin E2 (PGE2), tumour necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6).109–113 These cytokines may play a major role in tissue injury by inducing the expression and activation of MMPs and TIMPs.105

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    Supported in part by grants from the Alyce F. Salerno Foundation and the Violet Baldwin Family Research Fund.

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