Basic ScienceInflammation and Cytokine Signaling in Aneurysms
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Cited by (23)
CT signal heterogeneity of abdominal aortic aneurysm as a possible predictive biomarker for expansion
2014, AtherosclerosisCitation Excerpt :However, some aneurysms rupture at a smaller size [5–7], and many larger aneurysms grow to a considerable size without rupture [8]. Furthermore, patients who are in need of more frequent screening and early intervention need to be identified, and strategies for testing new medical therapies are required [9–12]. Apart from baseline AAA size, it is critical to develop non-invasive imaging techniques to detect characteristics predicting significant aneurysm growth.
Cleaved high molecular weight kininogen, a novel factor in the regulation of matrix metalloproteinases in vascular smooth muscle cells
2010, Biochemical PharmacologyCitation Excerpt :Furthermore, several investigators have found elevated levels of inflammatory cells and cytokines in aneurysmatic tissues, including IL-1α[16]. Hence, it has been hypothesized that cytokine stimulation may trigger increased production of MMPs by inflammatory and smooth muscle cells within the aortic wall [17]. Stimulation of human VSMCs with IL-1α has been demonstrated to enhance release of both MMP-9 and MMP-2 into the culture media [14].
Identification of a genetic variant associated with abdominal aortic aneurysms on chromosome 3p12.3 by genome wide association
2009, Journal of Vascular SurgeryWhole Genome-expression Profiling Reveals a Role for Immune and Inflammatory Response in Abdominal Aortic Aneurysm Rupture
2009, European Journal of Vascular and Endovascular SurgeryCitation Excerpt :The trigger for the recruitment of inflammatory and immune cells is not yet known, but may include the increased local production of chemotactic cytokines such as IL-8, MCP-1 and RANTES (regulated on activation normal T-cell expressed and secreted).26 Human and experimental AAA tissues have also been shown to produce abundant amounts of prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6).11,13,27,28 The contributions of various components of the immune and inflammatory system have also been tested in animal models of AAA.
A review of biological factors implicated in abdominal aortic aneurysm rupture
2005, European Journal of Vascular and Endovascular SurgeryCitation Excerpt :It is likely that inflammatory cells release a cascade of pro-inflammatory cytokines that results in the activation of proteolytic enzymes.108 Human and experimental AAA tissues have been shown to produce abundant amounts of prostaglandin E2 (PGE2), tumour necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6).109–113 These cytokines may play a major role in tissue injury by inducing the expression and activation of MMPs and TIMPs.105
Supported in part by grants from the Alyce F. Salerno Foundation and the Violet Baldwin Family Research Fund.