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Hemodynamically Driven Stent Strut Design

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Abstract

Stents are deployed to physically reopen stenotic regions of arteries and to restore blood flow. However, inflammation and localized stent thrombosis remain a risk for all current commercial stent designs. Computational fluid dynamics results predict that nonstreamlined stent struts deployed at the arterial surface in contact with flowing blood, regardless of the strut height, promote the creation of proximal and distal flow conditions that are characterized by flow recirculation, low flow (shear) rates, and prolonged particle residence time. Furthermore, low shear rates yield an environment less conducive for endothelialization, while local flow recirculation zones can serve as micro-reaction chambers where procoagulant and pro-inflammatory elements from the blood and vessel wall accumulate. By merging aerodynamic theory with local hemodynamic conditions we propose a streamlined stent strut design that promotes the development of a local flow field free of recirculation zones, which is predicted to inhibit thrombosis and is more conducive for endothelialization.

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Acknowledgments

This work was supported by the National Institutes of Health under NIH grants HL62250, HL096059 and Training Grant T32 HL07954. We thank Drs. Scott L. Diamond, Melissa D. Sánchez, Jennifer E. Clark, Josué Sznitman, and David A. Boger for their constructive criticism.

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Authors and Affiliations

  1. Institute for Medicine and Engineering, University of Pennsylvania, 1010 Vagelos Laboratories, 3340 Smith Walk, Philadelphia, PA, 19104-6383, USA

    Juan M. Jiménez & Peter F. Davies

  2. Department of Pathology and Laboratory Medicine, University of Pennsylvania, 1010 Vagelos Laboratories, 3340 Smith Walk, Philadelphia, PA, 19104-6383, USA

    Peter F. Davies

  3. Department of Bioengineering, University of Pennsylvania, 1010 Vagelos Laboratories, 3340 Smith Walk, Philadelphia, PA, 19104-6383, USA

    Peter F. Davies

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  1. Juan M. Jiménez
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Correspondence to Peter F. Davies.

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Jiménez, J.M., Davies, P.F. Hemodynamically Driven Stent Strut Design. Ann Biomed Eng 37, 1483–1494 (2009). https://doi.org/10.1007/s10439-009-9719-9

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