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Modeling Stented Coronary Arteries: Where We are, Where to Go

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Abstract

In the last two decades, numerical models have become well-recognized and widely adopted tools to investigate stenting procedures. Due to limited computational resources and modeling capabilities, early numerical studies only involved simplified cases and idealized stented arteries. Nowadays, increased computational power allows for numerical models to meet clinical needs and include more complex cases such as the implantation of multiple stents in bifurcations or curved vessels. Interesting progresses have been made in the numerical modeling of stenting procedures both from a structural and a fluid dynamics points of view. Moreover, in the drug eluting stents era, new insights on drug elution capabilities are becoming essential in the stent development. Lastly, image-based methods able to reconstruct realistic geometries from medical images have been proposed in the recent literature aiming to better describe the peculiar anatomical features of coronary vessels and increase the accuracy of the numerical models. In this light, this review provides a comprehensive analysis of the current state-of-the-art in this research area, discussing the main methodological advances and remarkable results drawn from a number of significant studies.

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Acknowledgments

Authors are supported by the project “RT3S—Real Time Simulation for Safer vascular Stenting” funded by the European Commission under the 7th Framework Programme, GA FP7-2009-ICT-4-248801 and by the project “Development of hybrid magnesium degradable stents with polymeric coating for medical application” funded by the Fondazione Cassa di Risparmio di Trento e Rovereto.

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  1. Laboratory of Biological Structure Mechanics, Structural Engineering Department, Politecnico di Milano, Piazza L. da Vinci, 32, 20133, Milan, Italy

    Stefano Morlacchi & Francesco Migliavacca

  2. Department of Bioengineering, Politecnico di Milano, Milan, Italy

    Stefano Morlacchi

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  1. Stefano Morlacchi
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  2. Francesco Migliavacca
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Correspondence to Francesco Migliavacca.

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Associate Editor Ender A Finol oversaw the review of this article.

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Morlacchi, S., Migliavacca, F. Modeling Stented Coronary Arteries: Where We are, Where to Go. Ann Biomed Eng 41, 1428–1444 (2013). https://doi.org/10.1007/s10439-012-0681-6

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