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A PET/CT-follow-up imaging study to differentiate takotsubo cardiomyopathy from acute myocardial infarction

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Abstract

Takotsubo cardiomyopathy (TTC) is still an under-recognized disease and little data exists on the coexistence of TTC and obstructive coronary artery disease. Our patient case of an 80-year-old female lady highlights the impact of a positron emission tomography/computed tomography (PET/CT) follow-up imaging study to delineate this unique entity from acute coronary syndrome (ACS). Furthermore, we show for the first time that coronary flow reserve and myocardial blood flow is globally impaired in TTC and not only restricted to the non-contracting parts. This indicates a global microcirculatory impairment effect of the heart in the acute stage of TTC. Our case also demonstrates that a transient metabolic defect is also involved in this disease. Follow-up imaging by PET/CT in our patient case unmasked TTC and facilitated to exclude the differential diagnosis of ACS.

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Authors and Affiliations

  1. Department of Cardiology, Cardiovascular Center, University Hospital Zurich, Ramistrasse 100, D-Rämi, 8091, Zurich, Switzerland

    Jelena R. Ghadri, Willibald Maier, Oliver Gaemperli, Thomas F. Lüscher & Christian Templin

  2. Cardiac Imaging Divison, Department of Radiology, University Hospital Zurich, Zurich, Switzerland

    Jelena R. Ghadri, Svetlana Dougoud, Philipp A. Kaufmann & Oliver Gaemperli

  3. Center for Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland

    Philipp A. Kaufmann & Thomas F. Lüscher

  4. Division of Cardiovascular Diseases, Mayo Clinic Rochester, Rochester, MN, USA

    Abhiram Prasad

Authors
  1. Jelena R. Ghadri
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  2. Svetlana Dougoud
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  3. Willibald Maier
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  4. Philipp A. Kaufmann
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  5. Oliver Gaemperli
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  6. Abhiram Prasad
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  7. Thomas F. Lüscher
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  8. Christian Templin
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Correspondence to Christian Templin.

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Ghadri, J.R., Dougoud, S., Maier, W. et al. A PET/CT-follow-up imaging study to differentiate takotsubo cardiomyopathy from acute myocardial infarction. Int J Cardiovasc Imaging 30, 207–209 (2014). https://doi.org/10.1007/s10554-013-0311-x

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  • DOI: https://doi.org/10.1007/s10554-013-0311-x

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