Elsevier

American Heart Journal

Volume 109, Issue 6, June 1985, Pages 1345-1352
American Heart Journal

Cardiac hypertrophy and arterial distensibility in essential hypertension

https://doi.org/10.1016/0002-8703(85)90364-3Get rights and content

Abstract

Echocardiographic determinations, left ventricular mass-volume ratio (MV), left ventricular end-systolic stress (ESS), carotidofemoral pulse wave velocity (PWV), and brachial artery compliance (BAC), deduced from pulsed Doppler measurements and from the Bramwell-Hill equation, were evaluated in 20 patients with sustained essential hypertension in comparison with 20 control subjects of the same age and sex. In hypertensive patients, MV ratio, ESS, and PWV were significantly increased while BAC was reduced. In the overall population, ESS was directly correlated with PWV (r = 0.73), and MV ratio was significantly correlated with PWV (r = 0.60), BAC (r = −0.70), and systolic arterial pressure (r = 0.71). No comparable results were observed with diastolic arterial pressure. PWV was unchanged after cadralazine, a dihydralazine-like substance, and was decreased with the same blood pressure reduction following nitrendipine, a new calcium-blocking agent. These results suggest that: (1) the distensibility of large arteries plays an important role in the maintenance of cardiac hypertrophy in hypertension, and (2) antihypertensive drugs may act differently on arterial distensibility with possible consequences on ESS and reversion of left ventricular hypertrophy.

References (42)

  • F Abi-Samra et al.

    Determinants of left ventricular hypertrophy and function in hypertensive patients

    Am J Med Suppl on Cardiac Hypertrophy

    (1983)
  • DB Rowlands et al.

    Assessment of left ventricular mass and its response to antihypertensive treatment

    Lancet

    (1982)
  • RS Jones

    The weight of the heart and its chambers in hypertensive cardiovascular disease with and without failure

    Circulation

    (1953)
  • RC Schlant et al.

    Echocardiographic studies of left ventricular anatomy and function before and after treatment of essential hypertension

    Am J Cardiol

    (1977)
  • ED Frohlich et al.

    Clinical-physiological correlations in the development of hypertensive heart disease

    Circulation

    (1971)
  • L Corea et al.

    Left ventricular wall thickness and plasma catecholamines in borderline and stable essential hypertension

    Eur Heart J

    (1982)
  • RC Tarazi

    The role of the heart in hypertension

    Clin Sci

    (1982)
  • RB Devereux et al.

    Effect of blood pressure control on LV hypertrophy and function in hypertension (abstr)

    Circulation

    (1980)
  • MM Ibrahim et al.

    Factors influencing cardiac hypertrophy in hypertensive patients

    Clin Sci

    (1981)
  • JIM Drayer et al.

    Cardiac muscle mass during vasodilation therapy of hypertension

    Clin Pharmacol Ther

    (1983)
  • JIM Drayer et al.

    Increased and decreased in ventricular septal thickness during diuretic therapy

    Clin Pharmacol Ther

    (1982)
  • Cited by (208)

    • The Effect of Ascending Aortic Repair on Left Ventricular Remodeling

      2022, American Journal of Cardiology
      Citation Excerpt :

      The afterload opposing LV ejection is roughly equivalent to the sum of the resistance of the vessels and the stiffness of the vessel wall, which is referred to as the vascular impedance. Correspondingly, several investigators found that reduced distensibility or increased impedance of the aorta is highly correlated with cardiac hypertrophy.17,26 The energetic load on the heart may increase after graft replacement because grafts are less compliant than the native aorta.27

    • Trajectories of Age-Related Arterial Stiffness in Chinese Men and Women

      2020, Journal of the American College of Cardiology
    • Contribution of panoramic radiography in the diagnosis of calcified carotid atheroma: Case report and literature review

      2015, Revista Portuguesa de Estomatologia, Medicina Dentaria e Cirurgia Maxilofacial
    • Validation of a method for quantifying carotid artery calcification from panoramic radiographs

      2013, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
    View all citing articles on Scopus

    Supported by a grant from the Institut National de la Santé et de la Recherche Médicale (INSERM), the Association pour l'Utilisation du Rein Artificiel (AURA), and the Délégation Générale de la Recherche Scientifique et Technique (DGRST), Paris.

    View full text