Clinical studyCardiovascular dynamics during orthostasis and the influence of intravascular instrumentation
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Load Dependency of Left Atrial Strain in Normal Subjects
2018, Journal of the American Society of EchocardiographyCitation Excerpt :This maximized the effects of the normal compensatory baroreflex response, caused by a more pronounced, acute reduction in preload from baseline. The changes in vital parameters observed in our study during tilting were consistent with the described normal baroreceptor reflex that follows postural changes in healthy individuals, and it is mainly the result of an increase in sympathetic activity, reflected by an increase in heart rate and arterial vasoconstriction in order to maintain constant blood pressure.32 We found that acute reductions in preload were also associated with changes in a wide range of echocardiographic parameters.
The Role of the Syncope Management Unit
2015, Cardiology ClinicsCitation Excerpt :The time and/or degree of stress required to provoke this response provide the measure of OT. Any technique used to determine OT should enable distinction between patients with orthostatic intolerance (of various causes) and asymptomatic control subjects; be highly reproducible, enabling evaluation of therapeutic interventions; and avoid invasive procedures, which are known to impair OT.55 Head-upright tilt testing (HUTT) was first described for the diagnosis of syncope in the late 1980s.56
The role of the syncope management unit
2013, Cardiac Electrophysiology ClinicsVasovagal syncope: New physiologic insights
2013, Cardiology ClinicsDelaying orthostatic syncope with mental challenge: A pilot study
2012, Physiology and BehaviorCitation Excerpt :For example, in nitro-glycerine induced vasovagal syncope studies [8] the effects of this drug on cardiac output make it difficult to ascertain what would be the hemodynamic responses in healthy or non-medicated subjects. Furthermore, intravenous cannulation is avoided, which has been shown to spuriously affect cardiovascular responses and orthostatic tolerance [9]. For details on the combined HUT and graded LBNP protocol, please refer to [10].