Experimental studyTermination of ventricular fibrillation in dogs by depolarizing a critical amount of myocardium☆
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Defibrillation threshold in elective subcutaneous implantable defibrillator generator replacements: Time to reduce the size of the pulse generator?
2024, International Journal of CardiologyLow-energy, single-pulse surface stimulation defibrillates large mammalian ventricles
2022, Heart RhythmCitation Excerpt :To extinguish all focal sources of reentry while also preventing the generation of new rotors, that is, the critical mass hypothesis, this new approach requires a very dense pattern of electrodes to be placed on the surface of large mammalian hearts. In defibrillation studies using field shocks,23 defibrillation success is highest when a voltage gradient of 5 V/cm is generated throughout 95% of the myocardium. Importantly, we achieved >95% refractory myocardium when capturing >75% of the EG with surface stimulation at only a fraction of the energy, which could be reduced even further with a more efficient means to target EG than line electrodes.
Cardioversion
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2021, Journal of Emergency MedicineOptogenetics for cardiac pacing, resynchronization, and arrhythmia termination
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2019, Computers in Biology and Medicine
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This study was supported in part by the Herman C. Krannert Fund, Indianapolis, Ind., Grants HL06308, HL-05963 and HL-05749 from the National Heart and Lung Institute, National Institutes of Health, Bethesda, Md. and the Indiana Heart Association, Indianapolis, Ind.