Outcomes of direct coronary angioplasty for acute myocardial infarction in candidates and non-candidates for thrombolytic therapy☆
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Cited by (107)
Acute ST-segment elevation myocardial infarction: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition)
2008, ChestCitation Excerpt :Although most evaluations of PCI have been in patients who are eligible to receive fibrinolysis, there may be substantial value of PCI in patients who may not be suitable for fibrinolytic therapy because of an increased risk of bleeding.23 While there are no randomized controlled trials evaluating the outcome of PCI for patients who present with STE MI but who are ineligible for fibrinolytic therapy, these patients are at increased risk for mortality,24 and it has been suggested that PCI be considered for achieving reperfusion in these patients.23–26 1.0.1.
Gender-Age Interaction in Early Mortality Following Primary Angioplasty for Acute Myocardial Infarction<sup>†</sup>
2006, American Journal of CardiologyCitation Excerpt :Subsequently, randomized trials have demonstrated that primary angioplasty is superior to thrombolytic therapy in decreasing cardiovascular morbidity and mortality.7 Moreover, primary angioplasty appears to be particularly beneficial in higher risk patient subsets.8,9 Consistent with this possibility, several studies have noted a decrease in mortality rates for women compared with men after primary angioplasty for AMI.10,11
Guidelines for percutaneous coronary interventions
2005, Revista Espanola de CardiologiaComparison of baseline characteristics, clinical features, angiographic results, and early outcomes in men vs women with acute myocardial infarction undergoing primary coronary intervention
2004, ChestCitation Excerpt :Studies16,17 have emphasized that primary PCI appears to be superior to thrombolytic therapy in terms of immediate restoration of normal coronary flow in the IRA and reduction of recurrent ischemia or reinfarction. Furthermore, primary PCI has been considered to be particularly beneficial in higher-risk patient subsets.17,22,23 However, there are few reports regarding the impact of primary PCI on early outcomes in women vs men.
Primary angioplasty with routine stenting compared with thrombolytic therapy in elderly patients with acute myocardial infarction
2003, American Heart JournalCitation Excerpt :Our results indicate a reduction in the incidence of reinfarction and in the need for repeat revascularization because of recurrent ischemia, with a significantly lower incidence of major bleeding complications in patients treated with primary angioplasty with routine stenting, compared with thrombolytic therapy, in elderly patients. Previous studies have yielded limited and conflicting data on the advantage of primary angioplasty compared with thrombolytic therapy in elderly patients with AMI.12,13,21–30 Earlier trials have suggested that high-risk patients with evolving infarction, associated with a high mortality rate, such as advanced age (>70 years), anterior infarction, persistent tachycardia, or cardiogenic shock, are most likely to benefit from immediate angioplasty.21,22
Interventional procedures in acute myocardial infarction
2001, American Heart JournalCitation Excerpt :O’Keefe et al8 reported that 96% of 1000 consecutive patients with acute MI were acceptable candidates for percutaneous intervention, whereas nearly two thirds of the group had at least relative contraindications to thrombolytic therapy. In addition, because of actual or perceived contraindications, it has been documented that many patients with acute ST elevation MI are not treated with thrombolytic therapy and that these “lytic-ineligible” patients have a higher mortality rate.9-11 Primary PCI can be performed in nearly all these patients with a success rate greater than 90%.
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This work was supported by a grant from the Education Committee, The Moses H. Cone Memorial Hospital, Greensboro, North Carolina, and by a grant from United States Catheters and Instruments division of CR Bard, Inc., Billerica, Massachusetts.