Brief reportHistologic characteristics of tissue excised during directional coronary atherectomy in stable and unstable angina pectoris
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Association of plaque characterization by intravascular ultrasound virtual histology and arterial remodeling
2005, American Journal of CardiologyCitation Excerpt :Previous IVUS and pathologic studies have shown that positive vessel remodeling is observed frequently in culprit lesions with unstable clinical presentation and plaque rupture.5,6,18 Observational studies by pathologists who used necropsy and atherectomy material showed that plaques that cause thrombosis are rich in lipid.19,20 The link between positive vessel remodeling and lipid-rich plaque may be macrophage-derived foam cell expression of the metalloproteinases,21 a group of proteins involved in cell matrix breakdown.
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- 1
Dr. Escaned is supported by the FPU programme of the Spanish Ministry of Science and Education.
- 2
Dr. MacLeod is a recipient of the British Heart Foundation International Research Fellowship.
- 3
Mr. de Jong is a grant recipient from the Dutch Heart Foundation.