Brief reportThe paradox of nitrates in patients with angina pectoris and angiographically normal coronary arteries
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Cited by (32)
Vasospastic angina: Past, present, and future
2023, Pharmacology and TherapeuticsPharmacologic Treatment of Patients With Myocardial Ischemia With No Obstructive Coronary Artery Disease
2018, American Journal of CardiologyCombining baseline distal-to-aortic pressure ratio and fractional flow reserve in the assessment of coronary stenosis severity
2015, JACC: Cardiovascular InterventionsCitation Excerpt :The reduction in SR from baseline to hyperemia is a poorly described phenomenon, suggested by Brown et al. (13) and appraised invasively in humans by Sambuceti et al. (20). Although the mechanisms underlying this hyperemic decrease in SR are unclear, it seems plausible to suggest that diffuse atherosclerosis or less likely paradoxical hyperemic epicardial vasoconstriction (by modifying the functional geometry of the stenosis and decreasing separation losses at the exit throat) could lead to this condition (21,22). Finally, almost one-half of these vessels (48.6%) presented an exhausted CFR.
Coronary microvascular dysfunction, microvascular angina, and treatment strategies
2015, JACC: Cardiovascular ImagingCitation Excerpt :Russo et al. (69) showed no significant change in stress test parameters after use of isosorbide dinitrate. Bugiardini et al. (70) observed worse angina and reduced CBF with rapid atrial pacing. Adenosine receptor blockade with members of the xanthine family, such as theophylline, were assessed in 6 small studies, none of which assessed MVD.
Pharmacological approaches to coronary microvascular dysfunction
2014, Pharmacology and TherapeuticsCitation Excerpt :Their efficacy appears to be disappointing in patients with chronic stable angina and no obstructive CAD. Indeed, the majority of studies have shown only a modest effect of sublingual and/or intracoronary nitrate therapy in time to angina and peak ST-segment depression of patients with microvascular angina (Bugiardini et al., 1993; Radice et al., 1994). In a recently published study, Russo et al. have assessed the effects of short-acting nitrates on exercise stress test (EST) results and the relation between EST results and coronary blood flow (CBF) response to nitrates in 29 patients with microvascular angina as compared to 24 patients with obstructive CAD.
Effects of lisinopril, atenolol, and isosorbide 5-mononitrate on angina pectoris and QT dispersion in patients with syndrome X: An open-label, randomized, crossover study
2002, Current Therapeutic Research - Clinical and Experimental
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Dr. Bugiardini's current address is: Istituto di Patologia Medica III, Policlinico S. Orsola, Via Massarenti, 9, 40138, Bologna, Italy.