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Impact of patient selection biases on the perception of hypertrophic cardiomyopathy and its natural history

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      A majority of these cases are diagnosed by providers in larger metropolitan healthcare facilities [3,7,8]. Less frequently is it seen among older patient populations in community hospital emergency department (ED) settings [7]. The National Heart, Lung, and Blood Institute (NHLBI) has deemed HCM as an unmet-need disease state due to a marked lack of original randomized controlled trials (RCTs) examining the pharmacological agents used for acute and chronic management of HCM [3].

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