Elafin is a potent inhibitor of proteinase 3
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Cited by (115)
A triple WAP domain containing protein acts in antibacterial immunity of weather loach, Misgurnus anguillicaudatus
2020, Fish and Shellfish ImmunologyCitation Excerpt :SLPI, a well-studied WAPD protein with antiprotease and antibacterial activities, prevents inflammation via inhibiting proteases released from neutrophils and protects the host against different kinds of pathogens [7–9]. The bactericidal activity is also found in several other mammalian WAPD proteins, such as milk WAP [10], human Elafin [11,12], and mouse SWAM1 and SWAM2 [13]. In lower vertebrates and invertebrates, there are also certain kinds of WAPD proteins studied.
Antimicrobial proteins and peptides in human lung diseases: A friend and foe partnership with host proteases
2016, BiochimieCitation Excerpt :Despite elafin shares 40% sequence identity with SLPI, the protease inhibitory domain is identical except for the P1 residue (Ala for elafin vs Leu for SLPI). This single mutation may explain why elafin has a more specific spectrum of inhibition than SLPI [69], since elafin inhibits proteinase 3 (Pr3) but not trypsin, chymotrypsin or Cat G [70,71]. Elafin displays potent antibacterial and antifungal activities against P. aeruginosa and S. aureus as well as C. albicans and A. fumigatus.
A functional variant of elafin with improved anti-inflammatory activity for pulmonary inflammation
2015, Molecular TherapyCitation Excerpt :Elafin expression is upregulated at various sites of inflammation by a range of proinflammatory mediators6,13,14,15 and may provide protection against neutrophilic proteases.16 Elafin is recognized as a potent inhibitor of a restricted set of serine proteases, namely neutrophil elastase (NE) and proteinase-3 (PR3).4,5,17,18 Trappin-2 and elafin have a number of transglutaminase (TG) reactive residues and therefore can be linked covalently to various extracellular matrix proteins such as fibronectin by tissue transglutaminases and retain potent antiprotease activity.19,20,21,22
Shrimp single WAP domain (SWD)-containing protein exhibits proteinase inhibitory and antimicrobial activities
2008, Developmental and Comparative ImmunologyComplex of human neutrophil elastase with 1/2SLPI
2008, Journal of Synchrotron Radiation