Research paperProcoagulant activity expression by macrophages from atheromatous vascular plaques
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Cited by (53)
Tissue factor pathway inhibitor [Tfpi]: A natural coagulation inhibitor and potential therapeutic agent - A review
2009, Journal of Taibah University Medical SciencesCitation Excerpt :The disruption of atherosclerotic plaque in coronary arteries is usually complicated by acute local thrombosis which leads to unstable angina and myocardial infarction 45. Such event of disruption exposes the monocyte/macrophage TF in these plaques 46,47 to circulating blood, resulting in the formation of a mural thrombus. However, TFPI colocalized with TF in endothelial cells, macrophages, and vascular smooth muscle cells plays a regulatory role in TF-induced thrombosis in atherosclerotic plaques 48–51.
Blood Coagulation and Atherothrombosis
2004, Molecular Basis of Cardiovascular Disease: A Companion to Braunwald's Heart DiseaseCoagulation pathways in atherothrombosis
2002, Trends in Cardiovascular MedicineOxidized LDLs influence thrombotic response and cyclooxygenase 2
2002, Prostaglandins Leukotrienes and Essential Fatty AcidsIntrinsic pathway of blood coagulation contributes to thrombogenicity of atherosclerotic plaque
2002, BloodCitation Excerpt :At the final stage, plaque rupture results in massive exposure to blood flow of plaque material depleted in SMCs and enriched in lipid-laden macrophage-derived foam cells. The highest oxLDL-induced increase in the procoagulant activity of this cell type in both the extrinsic pathway (24- to 30-fold56,57) and intrinsic pathway (20-fold in our experiments) may explain the burst of thrombogenicity of vulnerable atheromatous plaques, which is an acknowledged cause of sudden cardiac death. In conclusion, we demonstrated that in vitro treatment of human macrophages and SMC with oxLDL dramatically increases their ability to support thrombin formation via the intrinsic pathway, which is likely to be an additional mechanism determining thrombogenicity of the atherosclerotic plaque.
Monocyte function and plasma levels of interleukin-8 in acute ischemic stroke
2001, Journal of the Neurological Sciences