Atherosclerotic plaque caps are locally weakened when macrophages density is increased

doi:10.1016/0021-9150(91)90235-U

Atherosclerosis

Volume 87, Issue 1, March 1991, Pages 87-90

https://doi.org/10.1016/0021-9150(91)90235-U Get rights and content

Abstract

The density of macrophages, identified by the antibody EBMII, in human aortic plaque caps was counted. A contiguous strip of cap tissue was tested mechanically. Aortic plaque caps which had undergone rupture (ulceration) at one end (n = 18) were compared with caps of intact plaques (n = 22). The caps of ruptured plaques showed a significant increase in macrophage density, an increased extensibility and decreased maximum stress (force per unit area) at fracture when compared with caps from intact plaques.

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Atherosclerotic plaque caps are locally weakened when macrophages density is increased

Abstract

J. Atheroscler. Res.

J. Am. Coll. Cardiol.

J. Am. Coll. Cardiol.

Atherosclerosis

Exp. Mol. Pathol.

Plaque fissuring — the cause of acute myocardial infarction, sudden ischaemic death and crescendo angina

Br. Heart J.

The pathological basis and microanatomy of occlusive thrombus formation in human coronary arteries

Phil. Trans. R. Soc. Lond. (Biol.)

Plaque rupture with severe pre-existing stenosis precipitating coronary thrombosis. Characteristics of coronary atherosclerotic plaque underlying fatal occlusive thrombi

Br. Heart J.

Coronary thrombosis in pathogenesis of acute myocardial infarction, Histopathological study of coronary arteries in 108 necropsied cases

Br. Heart J.

Localisation of tissue factor in the normal vessel wall and in the atherosclerotic plaque