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Early-onset plasmapheresis and LDL-apheresis provide better disease control for pediatric homozygous familial hypercholesterolemia than HMG-CoA reductase inhibitors and ameliorate atherosclerosis
2013, Transfusion and Apheresis ScienceCitation Excerpt :Remarkably, in the study cohort, both apheresis modalities (PA and LDL-A) resulted in a reduction of up to 68% in LDL-C and disappearance of atherosclerotic plaques, with no increase in carotid IMT in all patients. These data are consistent with previous reports [20,21]. Echocardiographic evaluations recently performed in our study demonstrated normal tricuspid aortic valves, no supravalvular changes and normal carotid orifices in all patients and grade 1/4 aortic insufficiency in 4/5 patients.
Invasive Imaging Modalities and Atherosclerosis: The Role of Intravascular Ultrasound
2008, Clinical Lipidology: A Companion to Braunwald's Heart Disease Expert Consult: Online and PrintPractical aspects of direct adsorption of lipoproteins from whole blood by DALI LDL-apheresis
2004, Transfusion and Apheresis ScienceIntravascular ultrasound evaluation of coronary plaque regression by low density lipoprotein-apheresis in familial hypercholesterolemia: The low density lipoprotein-apheresis coronary morphology and reserve trial (LACMART)
2002, Journal of the American College of CardiologyCitation Excerpt :To our knowledge, the present study is the first one to directly evaluate the combined effect of lipid-lowering drug therapy and LDL-A on coronary plaque using IVUS in severe hypercholesterolemic patients with CAD. Regression and/or retardation of coronary atherosclerosis (15,16,18)and reduction of cardiac event (19)have proved to be the major treatment effects of LDL-A. Several possible mechanisms have been suggested for the reduction in cardiac events—for example, improvement in vascular endothelial functions (20), stabilization of plaques (21), prolongation in oxidizability of low density lipoprotein (22,23), reduction or suppression of the expression of adhesion molecules (24,25)and suppression of platelet activation (26). The present study is the first to focus on quantification of the changes occurring in atherosclerotic plaque after LDL-A therapy, and it has demonstrated marked regression of coronary plaques by measurement with IVUS.
Invasive Imaging Modalities and Atherosclerosis: The Role of Intravascular Ultrasound
2009, Clinical Lipidology: A Companion to Braunwald's Heart Disease