Elsevier

The Lancet

Volume 336, Issue 8719, 6 October 1990, Pages 827-830
The Lancet

MEDICAL SCIENCE
Risk of myocardial infarction and death during treatment with low dose aspirin and intravenous heparin in men with unstable coronary artery disease

https://doi.org/10.1016/0140-6736(90)92336-GGet rights and content

Abstract

796 men with unstable coronary artery disease (unstable angina or non-Q-wave myocardial infarction [MI]), were randomised to double-blind placebo-controlled treatment with oral aspirin 75 mg/day and/or 5 days of intermittent intravenous heparin. The risk of Ml and death was reduced by aspirin. After 5 days the risk ratio was 0·43 (confidence intervals, 0·21-0·91), at 1 month 0·31 (0·18-0·53), and at 3 months 0·36 (0·23-0·57). Aspirin reduced event rate in non-Q-wave Ml and unstable angina, independently of electrocardiographic abnormalities or concurrent drug therapy. Heparin had no significant influence on event rate, although the group treated with aspirin and heparin had the lowest number of events during the initial 5 days. Treatment had few side-effects and high patient compliance.

References (23)

  • Hd Lewis et al.

    Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina

    N Engl J Med

    (1983)
  • Cited by (0)

    Correspondence to Dr L. Wallentin, MD, Division of Cardiology, University Hospital, S-581 85 Linkoping, Sweden

    View full text