Elsevier

The Lancet

Volume 340, Issue 8827, 31 October 1992, Pages 1067-1068
The Lancet

SHORT REPORTS
Fatal myocardial infarction and use of psychotropic drugs in young women

https://doi.org/10.1016/0140-6736(92)93081-WGet rights and content

Abstract

We have observed an unexpected 17-fold increase in risk of total myocardial infarction (relative risk 16·9, 95% confidence interval 3·9-72·8) associated with current use of psychotropic drugs. This incidental finding, in a case-control study of cardiovascular mortality in women aged 16-39 not designed to test any hypothesis about psychotropic drugs, should be treated cautiously. There is, however, evidence of a relation between psychiatric morbidity and cardiovascular disease and the association recorded here requires further investigation.

References (11)

  • Dk Ahern et al.

    Biobehavioral variables and mortality or cardiac arrest in the cardiac arrhythmia pilot study (CAPS)

    Am J Cardiol

    (1990)
  • M. Thorogood et al.

    Is oral contraceptive use still associated with an increased risk of fatal myocardial infarction? Report of a case-control study

    Br J Obstet Gynaecol

    (1991)
  • M. Thorogood et al.

    Risk factors for fatal venous thromboembolism in young women: a case-control study

    Intern J Epidemiol

    (1992)
  • M. Thorogood, Ji Mann, M. Murphy, M. Vessey, Fatal stroke and oral contraceptive use: findings from a case-control...
  • Ne Breslow, Ne Day (Eds), Statistical methods in cancer research: vol I, the analysis of case-control studies,...
There are more references available in the full text version of this article.

Cited by (82)

  • Impact of Postoperative Zolpidem Use on Primary Total Knee Arthroplasty: A Retrospective Matched-Controlled Analysis of a Private Insurance Database

    2021, Journal of Arthroplasty
    Citation Excerpt :

    Zolpidem use was also associated with an increased incidence of MI and CVA. Several studies support a link between hypnotic use and cardiovascular events, although mediating mechanisms are not fully understood [39,40]. In a longitudinal panel survey study of 14,117 participants, Belleville found sedative drug use was associate with overall mortality, including circulatory conditions [OR: 1.316; 95% CI: 1.108–1.563, P = .002].

  • Antipsychotic drugs and venous thromboembolism

    2012, Thrombosis Research
    Citation Excerpt :

    Among other acquired risk factors of VTE, several reports are now available on the biochemical and clinical effect of antipsychotic drugs on VTE. Since the 1950s, when the first antipsychotic medications were developed, there have been reports of an increased prevalence of venous thromboembolism in patients treated with antipsychotics [3–8]. During the last decade the evidence has been strengthened with large epidemiological studies [9–21].

View all citing articles on Scopus
View full text