Reduction of reperfusion injury of human myocardium by allopurinol: A clinical study
References (34)
- et al.
Evaluation of the role of xanthine oxidase in myocardial reperfusion injury
J. Biol. Chem.
(1990) - et al.
Enhancement of cristalloid cardioplegic protection against global normothermic ischemia by superoxide dismutase plus catalase but not diltiazem in the isolated working rat heart
J. Thorac. Cardiovasc. Surg.
(1988) - et al.
Oxygen-derived free radical scavengers for amelioration of reperfusion damage in heart transplantation
J. Thorac. Cardiovasc. Surg.
(1988) - et al.
Prevention of free radical induced myocardial injury by allopurinol
J. Thorac. Surg.
(1988) - et al.
Myocardial protection with blood cardioplegia in ischemically injured hearts: Reduction of reoxigenation injury with allopurinol
Ann. Thorac. Surg.
(1988) - et al.
The role of the neutrophil and free radicals in ischemic myocardial injury
J. Mol. Cell. Cardiol.
(1989) - et al.
Urate production by human heart
J. Mol. Cell. Cardiol.
(1989) - et al.
Role of xanthine oxidase inhibitor as free radical scavenger: A novel mechanism of action of allopurinol and oxypurinol in myocardial salvage
Biochem. Biophys. Res. Comm.
(1987) - et al.
Allopurinol and oxypurinol are hydroxyl radical scavengers
FEBS Lett.
(1987) - et al.
Clastogenic factor in ischemia-reperfusion injury during open-heart surgery: Protective effect of allopurinol
Ann. Thorac. Surg.
(1988)
Superoxide anion production by postsurgical macrophages
J. Surg. Res.
Increased production of peroxide products associated with cardiac operations
J. Thorac. Cardiovasc. Surg.
Oxygen free radical scavengers protect the arrested, globally ischaemic heart upon reperfusion
Surg. Forum
Free radicals and cardioplegia: Organic anti-oxidants as additives to the St Thomas' Hospital cardioplegic solution
Cardiovasc. Res.
Oxidative tissue damage following regional intestinal ischemia and reperfusion in the cat
Res. Exp. Med.
Oxygen-derived free radicals in postischemic tissue injury
New Engl. J. Med.
Role of free neutrophils in canine myocardial reperfusion injury: Myocardial salvage by a novel free radical scavenger, 2-octadecylascorbic acid
Cardiovasc. Res.
Cited by (35)
Allopurinol as a therapeutic option in cardiovascular disease
2017, Pharmacology and TherapeuticsCitation Excerpt :These ‘leaked’ electrons combine with molecular oxygen to form superoxide anions (Burgoyne et al., 2013). Recognition of the importance of XO-derived ROS generation has prompted the evaluation of allopurinol in clinical models of IRI (Table 1 (Bochenek et al., 1990; Castelli et al., 1995; Coetzee, Roussouw, & Macgregor, 1996; Coghlan et al., 1994; Gimpel, Lahpor, van der Molen, Damen, & Hitchcock, 1995; Guan et al., 2003; Johnson, Kayser, Brenowitz, & Saedi, 1991; Movahed, Nair, Ashavaid, & Kumar, 1996; Parmley, Mufti, & Downey, 1992; Rashid & William-Olsson, 1991; Rentoukas et al., 2010; Sisto et al., 1995; Tabayashi et al., 1991; Taggart et al., 1994; Talwar et al., 2010)). In a randomised, placebo-controlled trial of 169 patients undergoing elective coronary artery bypass grafting (CABG) (Johnson et al., 1991), which has previously been shown to result in oxidative stress upon reperfusion (Chambers, 2007; Zakkar, Guida, Suleiman, & Angelini, 2015), the use of oral allopurinol reduced in-hospital mortality (4 vs. 18%, p = 0.014) and the need for post-operative inotropic or mechanical support (12 vs. 26%, p = 0.021).
Oxidative risk for atherothrombotic cardiovascular disease
2009, Free Radical Biology and MedicineAcrolein activates matrix metalloproteinases by increasing reactive oxygen species in macrophages
2009, Toxicology and Applied PharmacologyDoes allopurinol prevent side effects of cyclosporine-A treatment?
2002, Transplantation ProceedingsElevated serum uric acid levels are associated with diastolic dysfunction in patients with dilated cardiomyopathy
2002, American Heart JournalCitation Excerpt :A promising alternative strategy is the inhibition of xanthine oxidase with allopurinol. There is evidence that allopurinol may prevent free radical-induced myocardial damage.34 Furthermore, allopurinol improves endothelial function in patients with type 2 diabetes mellitus and mild hypertension.35
The role of oxidants and free radicals in reperfusion injury
2006, Cardiovascular Research