Clinical investigations: congestive heart failureC-reactive protein in acute myocardial infarction: association with heart failure
Section snippets
Patients
Three hundred and five unselected and consecutive patients admitted to 2 intensive-care units in 2 urban general hospitals for suspected AMI were prospectively studied. Thirty-three patients with preexisting or acute inflammatory process, neoplastic disease, or incomplete data collection, and 3 patients who died within 3 days after admission were excluded. Thus, the final analysis was performed in 269 subjects.
The patients were interviewed by a physician who completed a standard record form
Results
Of the 269 patients included in the study, 220 had evidence of AMI on the basis of the aforementioned criteria. The other 49 subjects were used as a control group. Of these, 32 manifested signs of unstable angina, 10 had chronic ischemic heart disease, and 7 had nonischemic diseases. The 2 groups were balanced for age and sex. Nitrates, antiplatelets, and anticoagulants were more frequently used in the patients with AMI (P = .006, P = .008 and P < .0001, respectively), and calcium-channel
CRP and congestive heart failure
Although several data support the role of inflammatory response in long-term clinical events in AMI,4, 5, 6 data defining the association between baseline CRP elevation and subsequent development of heart failure within this clinical entity is limited. A correlation between peak CRP levels and mortality from heart failure was described in 2 studies performed in small groups.13, 21 To our knowledge, the present study is the first to highlight the relationship between baseline CRP and occurrence
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2018, Food and Chemical ToxicologyCitation Excerpt :CRP-is a widely known as an acute phase protein that is produced by the liver in response to pro-inflammatory cytokines and chemokines. It has been suggested that increased CRP level is strongly associated with systemic inflammation (Berton et al., 2003). The serum levels CRP were found to be elevated in a population consuming high quantity of modern westernized diet (Inoue et al., 2016).
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