Right and left ventricular diastolic function in patients with and without heart failure: Effect of age, sex, heart rate, and respiration on Doppler-derived measurements☆,☆☆
Section snippets
Subjects
One hundred and forty subjects were recruited for the study. They consisted of two groups: patients with typical congestive heart failure and normal subjects.
Normal subjects
There was a significant correlation between LV diastolic parameters and age (Table I) . With increasing age, the mitral valve (MV) E wave decreased while the MV A wave increased, causing a modest decrease in MV E/A ratio and lengthening of LV IVRT. Similar observation was found in the right heart, although there was no significant effect on tricuspid valve (TV) A-wave velocity.
Heart failure
In patients with heart failure, the only positive correlation with increasing age in the LV was with the MV A wave (
Age and diastolic function
The effects of age on diastolic parameters in normal subjects have been noted by several investigators. However, the exact effect of age on different Doppler-identified measurements remains controversial. Iwase et al.10 and Zoghbi et al.8 described a group of normal subjects in which both mitral and tricuspid E-wave velocity and E/A ratio decreased with increasing age, whereas the A-wave velocity increased. However, Berman et al.6 found that mitral E wave did not correlate with age, whereas Pye
Acknowledgements
We thank Mrs. Anastasia Gates for typing the manuscript.
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