Integrated approaches to management of hypertension: Promoting treatment acceptance,☆☆,

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Abstract

Overwhelming trial evidence indicates that the treatment of hypertension is beneficial, but in practice, less than 50% of treated hypertensive subjects have blood pressure well controlled. The success of treatment relies on acceptance by the patient. Treatment acceptance may be affected by the efficacy and tolerability of drug therapy, its effects on quality of life, and other important but less well-recognized influences such as the expectations and preconceived ideas of the physician and the patient. This report briefly reviews the factors affecting patient concordance with antihypertensive treatment and the role these factors play in the development of an integrated treatment plan. Nonconcordance with drug therapy is common: Only one third of patients always take treatment, one third take it sometimes, and one third never take their prescribed medication. With poor concordance, control of blood pressure and the consequent benefits are less likely to be realized. The factors that influence concordance are ill understood. Although drug side effects and convenience of dosing regimens are contributors, the attitudes of patients, physicians, and their interactions are likely to be of considerable importance. Concordance may be improved by involving the patient in the treatment plan, setting explicit targets, following a clear treatment plan, motivating the patient to comply with treatment, paying attention to the concerns and particular needs of the individual patient, and by ensuring frequent contacts between patients and health care professions. Successful integrated approaches to the management of hypertension must address all the factors that affect treatment acceptance. (Am Heart J 1999;138:S252-S255.)

Section snippets

Efficacy, side effects, and quality of life during treatment of hypertension

Most antihypertensive agents have similar, modest efficacy.7, 8 Although the response to treatment varies between patients, monotherapy is insufficient in the majority. Some form of combination treatment is necessary in most patients to achieve target blood pressure, but most physicians appear reluctant to use more than one drug. The recent HOT study demonstrated that diastolic blood pressure could be reduced to below 90 mm Hg in almost 90% of patients and to below 80 mm Hg in nearly 60% of

Compliance and concordance

Used in combination, antihypertensive drugs can achieve target blood pressure in the vast majority of patients.13 Side effects are not prominent and, if drug treatment is used effectively to lower blood pressure to near normotensive levels, quality of life may ultimately improve. Despite the evidence of good tolerability in the clinical trial setting, in practice, there appears to be a belief among physicians and patients that antihypertensive medication, particularly in combination, causes an

Improving treatment concordance

In a survey of 843 general practitioners in the United Kingdom, the major reason for noncompliance was thought to be the occurrence of side effects, apathy, and failure to understand risk and treatment (Table I).

. General practitioners’ perceptions of reasons for loss of follow-up during treatment of hypertension

Empty CellPatients (%)
Failure to understand risk32
Apathy30
Side effects15
Failure to understand treatment15
Loss of prescription8
However, when practice nurses were questioned, they reported that

Conclusion

In conclusion, the management of hypertension is not as simple as was once thought. Hypertension is easily diagnosed, and a range of antihypertensive drugs are available. However, the success of treatment depends on whether the treatment is well accepted by the patient and taken as intended in the long term. Acceptance or nonacceptance may be affected by the efficacy and tolerability of the drug, its effects on quality of life, and other influences such as the expectations and preconceived

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From the Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary.

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Reprint requests: G. McInnes, MD, Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow, Scotland, UK. E-mail: [email protected]

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