Brief reportEffects of renal insufficiency on early invasive management in patients with acute coronary syndromes (The TACTICS-TIMI 18 Trial)
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2017, American Heart JournalCitation Excerpt :Large observational studies suggest that revascularization is beneficial in patients with renal dysfunction presenting with ACS but is associated with higher rates of procedural complications in this cohort.27-29 In TACTICS-TIMI 18, which compared a routine early invasive versus conservative strategy in patients with non–ST-elevation ACS, the benefits of routine early invasive strategy were preserved in patients with renal dysfunction at the expense of an increased risk of bleeding.30,31 Similarly, in STEMI patients with renal dysfunction, primary PCI is associated with reduced mortality during the index admission but higher rates of bleeding.32
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