Development and Validation of a Noninvasive Method to Determine Arterial Pressure and Vascular Compliance
Section snippets
Study Group
The Study Group Consisted of 56 Patients Undergoing Diagnostic Evaluation For Cardiovascular Disease at Ucsd Medical Center. the First Group Consisted of 36 Patients Undergoing only Left-Sided Cardiac Catheterization Who Were Used To Validate the accuracy of Systolic, Diastolic, and Mean arterial Pressure (map) Measurements. Detailed analysis Was also Performed in 14 of these Patients To Establish Measurement accuracy For the Rate of Pressure Change Derived From the Oscillometric Signal. an
Results
To assess the ability of this new method to provide accurate measurements, simultaneous pressures were obtained noninvasively and by intraarterial cannulation. Table 1 lists values for systolic, diastolic, pulse, and MAPs for both methods. A strong correlation was observed for invasive and noninvasive systolic (r = 0.94), diastolic (r = 0.91), and MAP (r = 0.95). Linear regression analysis of noninvasively and invasively derived pressures was performed for both systolic and diastolic pressures
Discussion
Examination of not only the level of arterial pressure but also the rate of pressure change are important in evaluating cardiovascular function.[12] Until recently, direct catheterization was the only technique used to evaluate pressure dynamics. However, invasive measurements may be time-consuming and expensive, are associated with potential patient risk and discomfort, and are thereby of limited use for many clinical applications. This study describes a new noninvasive technology that
Acknowledgements
We would like to thank the University of California, San Diego Medical Center catheterization laboratory staff for assistance in data collection during the catheterization procedures. In addition, we acknowledge the staff at the Hypertension Research Center, San Diego Veterans Administration Hospital, and Pulse Metric, Inc.
This study was supported by Pulse Metric, Incorporated, San Diego, California.
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