Acetylcholine-lnduced prolongation of the qt interval in idiopathic long qt syndrome*
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The use of isoproterenol and phenytoin to reverse torsade de pointes
2014, American Journal of Emergency MedicineCitation Excerpt :In such cases, isoproterenol infusion may cause degeneration into ventricular fibrillation and worse outcome [1]. Acetylcholine injection is known to cause QT prolongation and TdP in patients with congenital long QT syndrome [3]. Atropine is expected to increase the heart rate, thereby shortening the QTc interval and suppressing the arrhythmia, and has been successfully used in previous case reports [4].
Effect of atropine on QT prolongation and torsade de pointes induced by intracoronary acetylcholine in the long QT syndrome
1999, American Journal of CardiologyAutonomic nerve activity and long QT interval syndrome: A role of acetylcholine and alpha-adrenoceptor
1999, Journal of ElectrocardiologyMicturition Syncope.Not Always Benign
2023, CirculationSymptomatic long QT syndrome coexisting with asymptomatic acetylcholine-induced vasospasm
2021, Internal Medicine
- *
In conclusion, the following can be said from the present study: (1) Acetylcholine induced a prolongation of the QT interval only in patients with long QT syndrome. (2) Prolongation of the QT interval was reproducible and not due to a vehicle, bradycardia, or a decrease in blood pressure. (3) The mechanism of acetylcholine-caused prolongation of the QT interval is not known.
- 1
Dr. Aizawa's address is: the First Department of Internal Medicine, Asahimachi, Niigata 951, Japan. Manuscript received August 2, 1995.