Brief report
Relation of left ventricular chamber shape in patients with low (≤40%) ejection fraction to severity of functional mitral regurgitation

https://doi.org/10.1016/S0002-9149(99)80111-8Get rights and content

Abstract

In conclusion, the results of this study indicate that severity of functional MR in patients with low ejection fraction appears to be dictated primarily by increased sphericity of the left ventricle rather than by mitral annular dilatation or LV chamber enlargement.

Cited by (19)

  • Ventricular remodeling in children with left ventricular dysfunction secondary to various cardiomyopathies

    2005, American Journal of Cardiology
    Citation Excerpt :

    We found a strong inverse relation between LV systolic function indexes (shortening fraction or the EF) and LV sphericity. In adults, ventricular remodeling is associated with a decrease in the LVEF, exercise tolerance, and survival and an increase in functional MR and the development of heart failure symptoms.8–14 However, there are limited data in children.

  • Rationale and design of the multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy of vasopressin antagonism in heart failure: Outcome study with Tolvaptan (EVEREST)

    2005, Journal of Cardiac Failure
    Citation Excerpt :

    However, the study was underpowered with only 320 patients to detect significant differences in these end points. In a retrospective analysis, a trend toward lower total mortality was observed in the combined tolvaptan groups compared with placebo, particularly in patients with hyponatremia, renal dysfunction, or severe congestion at baseline.17 Tolvaptan has the potential to substantially advance the current management of congestion in heart failure.

  • Pharmacologic therapy for patients with chronic heart failure and reduced systolic function: Review of trials and practical considerations

    2003, American Journal of Cardiology
    Citation Excerpt :

    The systemic vasoconstriction translates into increased afterload, which further reduces cardiac performance. In patients with HF, a marked increase in the LV diastolic pressure may be responsible for changes in the shape of the left ventricle from an ellipsoid to a more spherical configuration.46,47 This change in ventricular geometry may result in papillary muscle rearrangement and secondary mitral insufficiency.48,49

View all citing articles on Scopus
View full text