Pharmacodynamic profile of prostacyclin
References (130)
- et al.
The enzymatic formation of prostaglandin E2 from arachidonic acid, prostaglandins and related factors
Biochim Biophys Acta
(1964) - et al.
The biosynthesis of prostaglandins
Biochim Biophys Acta
(1964) - et al.
Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation
Prostaglandins
(1976) - et al.
Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. An explanation for the antithrombotic properties of vascular endothelium
Thromb Res
(1977) - et al.
Circulatory and anti-platelet effects of intravenous prostacyclin in healthy men
Pharmacol Res Commun
(1978) - et al.
Prevention of blockage of partially obstructed coronary arteries with prostacyclin correlates with inhibition of platelet aggregation
Prostaglandins
(1979) - et al.
Modulation of human platelet adenylate cyclase by prostacyclin (PGX)
Prostaglandins
(1977) - et al.
Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets
Prostaglandins
(1977) - et al.
Stimulation of calcium uptake in platelet membrane vesicles by adenosine 3′, 5′-cyclic monophosphate and protein kinase
Biochim Biophys Acta
(1977) - et al.
Cyclic adenosine 3′, 5′-monophosphate and prostacyclin inhibit membrane phospholipase activity in platelets
Biochem Biophys Res Commun
(1977)
Cyclic AMP inhibits synthesis of prostaglandin endoperoxide (PGG2) in human platelets
Biochem Biophys Res Commun
(1976)
Effect of prostacyclin (PGI2) on platelet adhesion to rabbit arterial subendothelium
Prostaglandins
(1978)
Role of prostaglandins in the defense of the gastric mucosa
Brain Res Bull
(1980)
Studies on the protective effect of prostacyclin in acute myocardial ischemia
Eur J Pharmacol
(1979)
Prostacyclin in experimental myocardial ischemia: effects on hemodynamics, regional myocardial blood flow, infarct size and mortality
Am J Cardiol
(1981)
Prevention of infarction-induced decrease in circulating platelet count by prostacyclin
Thromb Res
(1980)
Prostacyclin prolongs viability of washed human platelets
Biochim Biophys Acta
(1982)
Effect of a glucocorticoid on prostaglandin production during simulated shock conditions in the perfused cat liver
Biochem Pharmacol
(1977)
Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig
Prostaglandins
(1975)
The influence of hydrocortisone and indomethacin on the release of prostaglandin-like substances during circulatory shock in cats, which was induced by an intravenous administration of rabbit blood
Pharmacol Res Commun
(1978)
Prostacyclin production by perturbed bovine aortic endothelial cells in culture
Blood
(1984)
The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes
J Biol Chem
(1990)
Lipopolysaccharide priming of alveolar macrophages for enhanced synthesis of prostanoids involves induction of a novel prostaglandin H synthase
J Biol Chem
(1992)
Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells
J Biol Chem
(1990)
The role of arginine: nitric oxide pathway in circulatory shock
Adv Pharmacol
(1994)
Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides
Prostaglandins
(1976)
A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation
Prostaglandins
(1976)
Further studies on the enzymatic conversion of prostaglandin endoperoxide into prostacyclin by porcine aorta microsomes
Biochim Biophys Acta
(1978)
The generation of prostacyclin by arteries and by the coronary vascular bed is reduced in experimental atherosclerosis in rabbit
Prostaglandins
(1977)
Biphasic response of intimal prostacyclin production during the development of experimental atherosclerosis
Prostaglandins
(1986)
Increased platelet aggregability is associated with increased prostacyclin production by vessel walls in hypercholesterolemic rabbits
Prostaglandins
(1982)
Prostacyclin generation in atherosclerotic arteries
Lancet
(1979)
Critical appraisal of the therapeutic value of α-tocopherol
Vitam Horn
(1962)
Prostaglandins and cyclic nucleotides: modulators of arterial cholesterol metabolism
Biochem Pharmacol
(1985)
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
Nature
(1971)
Zur Kenntnis der pharmakologischen Wirkungen von Nativsekreten und Extrakten männlicher accessorischer Geschlectsdrüssen
Arch Exp Pathol Pharmakol
(1934)
Isolation of prostaglandin E1 from human seminal plasma
J Biol Chem
(1962)
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
Nature
(1976)
Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides
Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells
Localisation and stimulation of prostacyclin production in vascular cells
Nature
(1978)
Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2 and prostacyclin
Pharmacol Rev
(1979)
Gastro-intestinal Mucosal Blood Flow
Prostacyclin production by isolated adipocytes
Diabetes
(1981)
The effect of prostacyclin (PGI2) on platelet behaviour, thrombus formation in vivo and bleeding time
Thromb Haemost
(1979)
Anti-aggregatory effect of prostacyclin (PGI2) in vivo
Br J Pharmacol
(1979)
Topical prostacyclin (PGI2) inhibits platelet aggregation in pial venules of the mouse
Stroke
(1979)
Cyclic adenosine 3′, 5′-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions
J Clin Invest
(1977)
The prostacyclin/thromboxane balance and cardiovascular disease
Clinical potential of prostacyclin
Adv Prostaglandins Thromboxane, Leukot Res
(1983)
Cited by (279)
Bronchopulmonary dysplasia – associated pulmonary hypertension: An updated review
2023, Seminars in PerinatologyVasorelaxing effect of Garcinia cowa leaf extract in rat thoracic aorta and its underlying mechanisms
2023, Journal of Traditional and Complementary MedicineCitation Excerpt :In addition to NO, a prostanoid, PGI2, is an important vasodilator derived from the endothelium, synthesized from arachidonic acid by enzymatic reaction of the cyclooxygenease (COX) pathway. PGI2 induces vascular smooth muscle relaxation by stimulating the adenylate cyclase to produce cyclic AMP that leads to a decrease in intracellular Ca2+, which, in turn, induces relaxation of vascular smooth muscle.24,25 The present finding shows that the vasorelaxing effect of G. cowa leaf extract was reduced when the thoracic aortic rings were pre-incubated with COX inhibitor indomethacin, suggesting that G. cowa leaf extract can stimulate prostanoid production and subsequently induce vasorelaxation.
Successful use of inhaled epoprostenol as rescue therapy for pediatric ARDS
2020, Respiratory Medicine Case ReportsAntihypertensive drugs and vasodilators
2018, Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application
Copyright © 1995 Published by Elsevier Inc.