Elsevier

The Lancet

Volume 352, Issue 9143, 5 December 1998, Pages 1829-1830
The Lancet

Research Letters
Homocysteine and folate in healthy east London Bangladeshis

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    Factors causing hyperhomocysteinemia include deficiencies of vitamin B6, vitamin B12, and folic acid; renal insufficiency; and genetic variants in enzymes responsible for homocysteine metabolism.90 Lower serum folate and elevated serum homocysteine levels were found in Bangladeshis in comparison to the Whites in a study carried out in UK; interplay between genetic and dietary factors were postulated to be the explanation.91 In a study involving 1650 adults in Bangladesh, prevalence of hyperhomocysteinemia (men: >11.4 μmol/L; women: >10.4 μmol/L) was 63% among men and 26% among women; folate and cobalamin deficiency, smoking and betel nut use were the possible associations.92

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    Asian Indians have been shown to have elevated homocysteine levels.43 Comparison studies in the United Kingdom and North America showed Asian Indians had a higher mean homocysteine level than Caucasians.44,45 Our study results did not reflect this trend of elevated homocysteine, with only a mean level of 10.43 ± 5.12.

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