Clinical trials of antioxidants in atherosclerosis: are we doing the right thing?
References (17)
The oxidation hypothesis of atherosclerosis
Lancet
(1994)- et al.
Effect of probucol treatment on the susceptibility of low density lipoprotein isolated from hyercholesterolemic patients to become oxidatively modified in vitro
Atherosclerosis
(1990) - et al.
Risk of angina pectoris and plasma concentrations of vitamins A, C, E and carotene
Lancet
(1991) - et al.
Autoantibody against oxidised LDL and progression of carotid atherosclerosis
Lancet
(1992) - et al.
Beyond cholesterol: modifications of low density lipoprotein that increase its atherogenicity
N Engl J Med
(1989) - et al.
A comparison of the antiatherogenic effects of probucol and of a structural analog of probucol in LDL receptor-deficient rabbits
J Clin Invest
(1994) - et al.
Antioxidants in the prevention of human atherosclerosis
Circulation
(1992) - et al.
Beta carotene therapy for chronic stable angina
Circulation
(1990)
Cited by (187)
Cytoprotective Effects of Polyphenols against Oxidative Damage
2013, Polyphenols in Human Health and DiseaseThermal effects on the structure of cereal starches. EPR and Raman spectroscopy studies
2013, Carbohydrate PolymersCitation Excerpt :It allows investigation of the changes occurring in the radical content and their structures during processes of their formation and vanishing. The short-time radicals can damage the living cells (Ashok & Ali, 1999; Babbs, 1990; Finkel & Holbrook, 2000; Steinberg, 1995) and lead to different diseases. On the other hand, long-lived radicals in polysaccharides can be considered as traps for free electrons, neutralizing in this way the dangerous reactive species (Filek, Kościelniak, Łabanowska, Bednarska, & Bidzińska, 2010; Łabanowska et al., 2012).
Chance and serendipity in science: Two examples from my own career
2011, Journal of Biological ChemistryCitation Excerpt :Disappointingly, with almost no exceptions, these clinical trials failed to show benefit. However, as discussed elsewhere (47, 48), the oxidative modification hypothesis is not refuted by the clinical trials to date. Briefly put, the antioxidants used may not have been the most effective in the human disease, the doses may have been inappropriate, or the patients may have been too old and the disease too far advanced to respond to antioxidant therapy.
Influence of copper catalyst on the mechanism of carbohydrate radicals generation in oxidized potato starch
2011, Carbohydrate PolymersCitation Excerpt :The electron paramagnetic resonance (EPR) technique was very useful to detect both the copper ions and the radical species because of their paramagnetic character. The study of radicals behaviour is of particular interest in view of the damaging role played by reactive free radicals in living cells (Ashok & Ali, 1999; Babbs, 1990; Finkel & Holbrook, 2000; Steinberg, 1995). On the other hand, the radicals with high stability can be considered as spin traps for dangerous short living paramagnetic species.