Clinical study: acute coronary syndrome
Angiotensin-converting enzyme inhibition is associated with reduced troponin release in non–ST-elevation acute coronary syndromes

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Abstract

OBJECTIVES

This study was done to determine the effects of angiotensin-converting enzyme (ACE) inhibition and other clinical factors on troponin release in non-ST-elevation acute coronary syndrome (ACS).

BACKGROUND

Troponin is now widely used as a marker of risk in ACS, but determinants of its release have not been defined.

METHODS

This was a prospective cohort study of 301 consecutive patients admitted with non–ST-elevation ACS. Baseline clinical data were recorded, ACE gene polymorphism was determined and serial blood samples were obtained for troponin-I assay.

RESULTS

Significant troponin-I release (>0.1 μg/l) was detected in 93 (31%) patients. Pretreatment with ACE inhibitors, recorded in 53 patients (17.6%), independently reduced the odds of troponin-I release (odds ratio 0.25; 95% confidence intervals 0.10 to 0.64) and was associated with lower maximum troponin-I concentrations (median [interquartile range]) compared with patients not pretreated with ACE inhibitors (0.44 μg/l [0.19 to 2.65 μg/l] vs. 4.18 μg/l [0.91 to 12.41 μg/l], p = 0.01). Pretreatment with aspirin, recorded in 173 patients (57.5%), did not significantly reduce the odds of troponin-I release after adjustment but was associated with lower maximum troponin-I concentrations compared with patients not pretreated with aspirin (2.31 μg/l [0.72 to 8.02 μg/l] vs. 5.85 μg/l [1.19 to 12.79 μg/l], p = 0.05). The ACE genotyping (n = 268) showed 81 patients (30%) DD homozygous and 77 (29%) II homozygous. There was no association between ACE genotype and troponin release.

CONCLUSIONS

We conclude that ACE inhibition reduces troponin release in non-ST-elevation ACS. This is likely to be mediated by the beneficial effects of treatment on vascular reactivity and the coagulation system.

Abbreviations

ACE
angiotensin-converting enzyme
ACS
acute coronary syndromes
CAD
coronary artery disease
ECG
electrocardiogram, electrocardiographic
MI
myocardial infarction

Cited by (0)

Biochemical assays were funded by Bayer Plc, Newbury, United Kingdom.