Clinical research: invasive and interventional cardiology
Clinical outcome of patients undergoing non-cardiac surgery in the two months following coronary stenting

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Abstract

Objectives

We sought to determine the frequency and timing of complications at our institution when surgery was performed within two months of coronary stent placement.

Background

The optimal delay following coronary stent placement prior to non-cardiac surgery is unknown.

Methods

We analyzed the Mayo Clinic Percutaneous Coronary Intervention and Surgical databases between 1990 and 2000 and identified 207 patients who underwent surgery in the two months following successful coronary stent placement.

Results

Eight patients (4.0%) died or suffered a myocardial infarction or stent thrombosis. All 8 patients were among the 168 patients (4.8%, 95% confidence interval [CI] 2.1 to 9.2) undergoing surgery six weeks after stent placement; the frequency of these events ranged from 3.8% to 7.1% per week during each of the six weeks. No events occurred in the 39 patients undergoing surgery seven to nine weeks after stent placement (0%, 95% CI 0.0 to 9.0).

Conclusions

These data suggest that, whenever possible, non-cardiac surgery should be delayed six weeks after stent placement, by which time stents are generally endothelialized, and a course of antiplatelet therapy to prevent stent thrombosis has been completed.

Abbreviations

CABG
coronary artery bypass graft surgery
CI
confidence interval
INR
International Normalized Ratio
MI
myocardial infarction
NHLBI
National Heart, Lung, and Blood Institute
TIMI
Thrombolysis In Myocardial Infarction

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