Clinical StudiesHMG-CoA Reductase Inhibitors Decrease CD11b Expression and CD11b-Dependent Adhesion of Monocytes to Endothelium and Reduce Increased Adhesiveness of Monocytes Isolated From Patients With Hypercholesterolemia☆
It was presented in part at the 17th Congress of the European Society of Cardiology, Amsterdam, The Netherlands, August 1995 and published in abstract form (Eur Heart J 1995;16:273).
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Abbreviations
CHD
coronary heart disease
GTP
guanosine triphosphate
HDL
high density lipoprotein
HMG-CoA
3-hydroxy-3-methyl-glutaryl coenzyme A
HUVECs
human umbilical vein endothelial cells
ICAM-1
intercellular adhesion molecule-1
LDL
low density lipoprotein
mAb
monoclonal antibody
MCP-1
monocyte chemoattractant protein-1
PBMCs
peripheral blood mononuclear cells
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This study was funded in part by Grants We 681/7-1 and We 1913/1 from the Deutsche Forschungsgemeinschaft, Bonn, Germany.
Copyright © 1997 The American College of Cardiology. Published by Elsevier Inc. All rights reserved.