Noncompaction of the Ventricular Myocardium☆,☆☆
Section snippets
History
A 57-year-old white woman was evaluated at our institution for progressive heart failure. She had no symptoms until age 51 years, when she began to have progressive left heart failure, intermittently associated with paroxysms of atrial fibrillation. The patient did not have chest pain, ventricular arrhythmias (symptomatic or detected with 24-hour Holter monitoring), or systemic embolic episodes. A dual-chamber pacemaker was implanted shortly after the onset of heart failure because of
Normal Versus Abnormal Endomyocardial Embryogenesis
During the first month of fetal life, before the development of the coronary circulation, the human embryonic myocardium consists of a “spongy” meshwork of interwoven myocardial fibers forming trabeculae with deep intertrabecular recesses.3, 4 These recesses communicate with the LV cavity, and blood is supplied to the myocardium through the intertrabecular spaces, resembling the myocardial blood supply in cold-blooded species. During weeks 5 to 8 of fetal life, 2 parallel processes normally
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Cited by (172)
Lack of morphometric evidence for ventricular compaction in humans
2021, Journal of CardiologyHypertrabeculation; a phenotype with Heterogeneous etiology
2021, Progress in Cardiovascular DiseasesEffect of Noncompacted Myocardial Resection on Isolated Left Ventricular Noncompaction
2020, Annals of Thoracic SurgeryCitation Excerpt :Although removing noncompacted trabeculae that cause thrombus formation can prevent embolism, the procedure may be used to treat heart failure by improving both the LV diastolic and systolic function.6-8 According to Agmon and colleagues,7 diastolic dysfunction in LVNC is related to both abnormal relaxation and restrictive filling caused by the numerous prominent and fibrous trabeculae. Therefore removing noncompacted trabeculae that restrict ventricular relaxation and filling might restore diastolic function.
Left Heart Anomalies
2016, Practice of Clinical EchocardiographyLeft ventricular noncompaction: A rare indication for pediatric heart transplantation
2016, Revista Portuguesa de CardiologiaContractile function and heart failure
2015, Advanced Cardiac Imaging
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Reprint requests: James B. Seward, MD, Mayo Clinic, 200 First St SW, Rochester, MN 55905.
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