Relation of degree of physical activity to coronary artery calcium score in asymptomatic individuals with multiple metabolic risk factors
Section snippets
Methods
This is a cross-sectional study of 779 asymptomatic patients who had multiple metabolic risk factors and who were referred by physicians for cardiac risk assessment with CAC imaging by electron beam tomography to a single imaging center from 1999 to 2002. These patients provided details of their medical histories through a detailed questionnaire. All the patients had ≥2 of the following metabolic risk factors: high blood pressure (>130/85 mm Hg), obesity (body mass index ≥30 kg/m2),
Results
Baseline demographics of the study cohort are presented in Table 1. Overall, 287 patients (37%) reported no PA, 205 (26%) reported moderate-duration PA, and 287 (37%) reported long-duration PA. Absolute median CAC scores were 24 (no-PA group), 18 (moderate-duration PA group), and 11 (long-duration PA group; p <0.002). Similarly, 75th percentile absolute CAC scores were 248 (no-PA group), 118 (mild to moderate-duration PA group), and 75 (long-duration PA group; p <0.001).
The distribution of
Discussion
This study examined the association between different degrees of PA and CAC in asymptomatic patients who had multiple metabolic risk factors. We included patients with a metabolic score ≥2 because it has been demonstrated that distribution of metabolic risk factors typically follows a Gaussian pattern and that most asymptomatic patients would have a metabolic score of 2 to 3.1 Further, it has been demonstrated that, as metabolic score increases (even at 3, which is the currently accepted
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This work was supported by unrestricted grants from the Harteveldt-Gomprecht Charitable Foundation, Baltimore, Maryland, and the Maryland Athletic Club, Timonium, Maryland.