Brief reportsComparison of the strain Doppler echocardiographic features of familial amyloid polyneuropathy (FAP) and light-chain amyloidosis
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Cited by (33)
Left ventricular deformation and torsion assessed by speckle-tracking echocardiography in patients with mutated transthyretin-associated cardiac amyloidosis and the effect of diflunisal on myocardial function
2015, IJC Heart and VasculatureCitation Excerpt :Speckle tracking echocardiography (STE) allows the evaluation of different components of complex cardiac motions, such as longitudinal, circumferential, and radial strain, and rotation [15–18]. Many studies have focused on light-chain associated cardiac amyloidosis, but few data concerning mutated transthyretin-associated (ATTRm) amyloidosis have been derived using strain echocardiography [19–21]. The purpose of this study was to clarify whether STE could detect early regional myocardial dysfunction in ATTRm amyloidosis, before the onset of CHF, and to determine whether change in regional myocardial deformation can be detected by STE in these patients after oral small-molecule treatment by diflunisal [20].
Impact of clinical and echocardiographic characteristics on occurrence of cardiac events in cardiac amyloidosis as proven by endomyocardial biopsy
2014, International Journal of CardiologyCitation Excerpt :Finally, we did not perform echocardiographic strain imaging [29,30], which would be valuable to stratify the risk among cardiac amyloidosis. These techniques also have the potential to differentiate between TTR and AL cardiac amyloidosis [31]. Future imaging techniques will be needed to aid in determining the subtypes of cardiac amyloidosis.
Amyloidosis. Also a heart disease
2011, Revista Espanola de CardiologiaRelation of clinical, echocardiographic and electrocardiographic features of cardiac amyloidosis to the presence of the transthyretin V122I allele in older African-American men
2011, American Journal of CardiologyCitation Excerpt :Establishing the diagnosis allows clinicians to avoid drugs that may be dangerous in patients with cardiac amyloidosis.21,22 Since the completion of these studies, newer echocardiographic and imaging techniques allowing better assessments of the quality and function of the myocardium have been validated in cardiac amyloidosis.23–26 However, even without these modalities, our data indicate that African American men aged >60 years carrying the amyloidogenic TTR V122I allele who are referred for cardiac evaluation on clinical grounds show electrocardiographic abnormalities and echocardiographic features associated with cardiac amyloidosis more frequently than matched allele-negative controls.
Amyloid Heart Disease
2010, Progress in Cardiovascular DiseasesCitation Excerpt :Tissue Doppler imaging can evaluate longitudinal contraction of the heart, and tissue Doppler velocities are impaired both in true left ventricular hypertrophy and amyloid heart disease. Longitudinal systolic dysfunction measured by tissue Doppler is universal and is disproportionately severe in amyloid heart disease compared both to other types of heart disease and to the degree of left ventricular ejection fraction impairment.11-14 The combined appearance of transmitral Doppler and tissue Doppler frequently suggests an elevated left ventricular end diastolic pressure and/or a restrictive left ventricular filling pattern.
Evaluation and Management of the Cardiac Amyloidosis
2007, Journal of the American College of CardiologyCitation Excerpt :If either a thickened interatrial septum or a granular highly echogenic myocardium is also present, this makes the diagnosis even more likely (30). Combining features has been shown to be good at differentiating cardiac amyloid from other diagnoses (40,41), though the most useful method is to combine these with the wider clinical findings. Systematic study of ECG findings in biopsy-confirmed cardiac amyloidosis is relatively sparse.